- 1. 4-Androstene-3,17-dione
- [delta-4 C19 steroid that is produced in the testes, ovaries and adrenal cortex and can serve as a precursor to testosterone as well as estrone and estradiol. ( CSP )] (UMLS (NCI) C0002860) =Steroid; Pharmacologic Substance; Hormone
| - 18. Androgen Receptor
- [Encoded by human AR Gene (NR3 Family), the Androgen Receptor transcription factor regulates gene expression, cell proliferation, and differentiation. AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. Polyglutamine expansion causes Kennedy's disease. Other mutations are associated with androgen insensibility syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1447749) AR;
DHTR;
Dihydrotestosterone Receptor;
NR3C4 =Amino Acid, Peptide, or Protein; Receptor |
- 2. AN-9/Docetaxel
- (UMLS (NCI) C1328148) =Therapeutic or Preventive Procedure ;
| - 19. Androgen Receptor (Dihydrotestosterone Receptor; Testicular Feminization; Spinal and Bulbar Muscular Atrophy; Kennedy Disease) Gene
- [This gene plays a role in the transcriptional activation of androgen responsive genes. ( NCI )] (UMLS (NCI) C1367578) Androgen Receptor Gene;
AR;
AR Gene =Gene or Genome |
- 3. and
- [This condition must be true. ( HL7V3.0 )] (UMLS (HL7) C1550557) =Idea or Concept =RelationshipConjunction;
| - 20. Androgen Receptor-Associated Protein
- [ARA(70), encoded by proto-oncogene NCOA4, is a ligand-dependent co-activator protein that enhances specific AR transcriptional activity. The androgen receptor is a transcription factor of the steroid receptor superfamily. Although several steroid-class receptors recognize the same DNA regulatory sequence, gene-specific activation may be achieved by selective accessory factors that interact with the receptors to determine specificity of target gene activation. (from OMIM 601984 and NCI) ( NCI )] (UMLS (NCI) C1335075) Androgen Receptor-Specific Coactivator;
ARA70;
ARA70/ELE1;
ELE1;
NCOA4;
NCOA4 Protein;
Nuclear Receptor Coactivator 4;
RET Activating Protein ELE1;
RFG =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4. Andalusian
- (UMLS (HL7) C1553359) =Population Group =Spaniard;
| - 21. Androgen Therapy
- (UMLS (NCI) C0279493) =Therapeutic or Preventive Procedure
|
- 5. Andean potato mottle virus
- [ ] (UMLS (CSP) C0598201) =Virus
| - 22. Androgen-Induced Proliferation Inhibitor Gene
- [This gene is involved in cell cycle regulation. ( NCI )] (UMLS (NCI) C1332105) APRIN;
APRIN Gene =Gene or Genome ;
|
- 6. Andriol
- (UMLS (NCI) C0592050) =Steroid; Pharmacologic Substance ;
| - 23. Androgen-Induced Prostate Proliferative Shutoff Associated Protein
- [Putative regulator of androgen-induced proliferative prostate cell arrest; may interact with other proteins and bind DNA; contains leucine-zipper, DNA- and ATP-binding motifs. (LocusLink) ( NCI )] (UMLS (NCI) C1332106) APRIN;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 7. Androblastoma
- [A sex cord-stromal tumor of the testis or the ovary. It is characterized by the presence of Sertoli cells forming tubules. Leydig cells are rare or absent. It may be associated with Peutz-Jeghers syndrome. In males, the presenting symptom is a slow growing testicular mass. Most cases follow a benign clinical course. In females it may present with estrogenic or androgenic manifestations. The vast majority of cases have a benign clinical course. ( NCI )] (UMLS (NCI) C0036769) =Neoplastic Process =Neoplasms, Gonadal Tissue;
| - 24. ANDROGRAPHOLIDE
- (UMLS (NCI) C0051821) =Pharmacologic Substance
|
- 8. Androcur
- (UMLS (NCI) C0699709) =Steroid; Pharmacologic Substance ;
| - 25. Android
- (UMLS (NCI) C0718532) Android brand of methyltestosterone =Steroid; Pharmacologic Substance; Hormone
|
- 9. androgen
- [compounds that interact with androgen receptors in target tissues to bring about the effects similar to those of testosterone; depending on the target tissues, androgenic effects can be on sexual differentiation, male reproductive organs, spermtogenesis, secondary male sex characteristics, libido, development of muscle mass, strength, and power. ( CSP )] (UMLS (CSP) C0002844) =Pharmacologic Substance; Hormone ;
| - 26. Android-F
- (UMLS (NCI) C0733925) =Steroid; Pharmacologic Substance ;
|
- 10. androgen analog
- [steroidal compounds related to testosterone. ( CSP )] (UMLS (CSP) C0002845) =Pharmacologic Substance; Hormone ;
| - 27. andromedotoxin
- [ ] (UMLS (CSP) C0061887) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 11. Androgen Antagonists
- [(an-tee-AN-dro-jens) Drugs used to block the production or interfere with the action of male sex hormones. ( NCI )] (UMLS (NCI) C0002842) =Pharmacologic Substance
| - 28. Androst-5-en-17-one
- (UMLS (NCI) C0385259) =Steroid
|
- 12. androgen binding protein
- [family of soluble blood carrier proteins which transport androgens from endocrines to target tissues; do not confuse with ANDROGEN RECEPTOR, which is an intracellular protein. ( CSP )] (UMLS (CSP) C0002843) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 29. Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)-
- [The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. ( NCI )] (UMLS (NCI) C0126177) =Steroid; Pharmacologic Substance ;
=Androstadienes;
LOTEPREDNOL =LOTEPREDNOL ETABONATE 0.5 %;
LOTEPREDNOL ETABONATE 0.2 %;
|
- 13. androgen independent prostate cancer
- [ ] (UMLS (CSP) C1654637) =Neoplastic Process
| - 30. androstane
- [any substance that is made by combining two or more elements with the 19-carbon tetracyclic hydrocarbon that is the parent structure of the androgens. ( CSP )] (UMLS (CSP) C0002854) =Steroid; Biologically Active Substance ;
|
- 14. androgen independent prostate neoplasm
- [ ] (UMLS (CSP) C1328827) =Neoplastic Process ;
| - 31. androstenediol
- [Unsaturated androstane derivatives which are substituted with two hydroxy groups in any position in the ring system. ( MSH )] (UMLS (CSP) C0002859) =Steroid
|
- 15. Androgen insensitivity syndrome
- [A familial form of PSEUDOHERMAPHRODITISM transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY. ( MSH )] (UMLS (ICD9CM) C0039585) =Disease or Syndrome
| - 32. Androstenedione Aromatase Inhibitor
- [An agent that blocks the function of the enzyme aromatase with antineoplastic activity. Aromatase inhibitors belong to two classes: Type I steroidal drugs are androgen substrate analogues that bind competitively but irreversibly to the enzyme. Type II nonsteroidal inhibitors fit into the substrate binding site and bind reversibly to the enzyme. Present in many tissues, aromatases are heme-containing enzymes that catalyze the adrenal conversion of cholesterol to pregnenolone and the peripheral conversion (aromatization) of androgenic precursors to estrogens. (NCI04) ( NCI )] (UMLS (NCI) C0593802) =Pharmacologic Substance ;
=enzyme inhibitor;
|
- 16. Androgen Metabolism
- [Androgen Metabolism consists of diverse biochemical reactions in the adrenal cortex that produce 19-carbon steroid hormones, which promote male sexual development or convert such steroids to metabolic derivatives. ( NCI )] (UMLS (NCI) C1158330) =Molecular Function
| - 33. androsterone
- [A steroid metabolite derived from sex hormones, which displays weak androgenic properties. In testes is formed from progesterone. Androsterone sulfate is clinically recognized as one of the major androgen metabolites found in urine, in males and females. It is made in the liver from the metabolism of testosterone. Androsterone glucuronide, a dihydrotestosterone metabolite, is present in serum. Androsterone is a weak anabolic hormone. (NCI04) ( NCI )] (UMLS (CSP) C0002865) =Steroid; Hormone ;
|
- 17. androgen receptor
- [proteins, generally found in the cytoplasm, that specifically bind androgens and mediate their cellular actions. ( CSP )] (UMLS (CSP) C0034786) =Amino Acid, Peptide, or Protein; Receptor ;
=Steroid Hormone Receptor;
| - 34. Androtardyl
- (UMLS (NCI) C0733489) =Steroid; Pharmacologic Substance; Hormone
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