[Related to 'apterous' (Drosophila) and encoded by human LHX2 Gene (LIM/Homeobox Family), 406-amino acid 44-kD nuclear LIM Homeobox Protein 2 is a putative transcription factor containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM2 may control differentiation and development of neural and lymphoid cells. Rodent LH2 is expressed in the central nervous system and in immature B- and T-cells. In the pituitary, mouse Lh2 regulates expression of the pituitary glycoprotein hormone alpha subunit. High expression is observed in chronic myelogenous leukemia (CML). (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0527482 - Amino Acid, Peptide, or Protein
- Biologically Active Substance