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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
H H+ H1 HA HB HC HD HE HF HG HH HI HK HL HM HN HO HP HQ HR HS HT HU HV HX HY HZ
HEA HEB HEC HED HEE HEF HEI HEL HEM HEN HEP HER HES HET HEU HEV HEX HEY

Hepatocyte Nitric Oxide Synthase

[Induced by lipopolysaccharide, endotoxins, and cytokines and expressed as 2 alternative isoforms in liver, retina, bone cells, and airway epithelia by human NOS2A Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2A binds FAD and FMN cofactors, contains a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2A binds SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. Aspirin inhibits NOS2A. (NCI) ( NCI )]
UMLS (NCI) C0669372
 
Amino Acid, Peptide, or Protein
Enzyme

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