CCNE1

1. [Cyclin E1, a protein encoded by the CCNE1 gene, forms a complex with and functions as a regulatory subunit of CDK2, whose activity is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 accumulates at the G1-S phase boundary and phosphorylation by CDK2 triggers its release from CDK2 and degradation. Overexpression of this gene is observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis. Cyclin E1 is associated with and involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two isoforms, E1L and E1S, are produced by alternative splicing and E1S cannot complex with CDK2. Cyclin E1 is highly expressed in testis and placenta with low levels in bronchial epithelial cells. (NCI) ( NCI )]
   UMLS (NCI) C1259807
   
   Cyclin E
   Cyclin E1
   Cyclin Es
   Cyclin Et
   
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance
   

2. [This gene regulates the G1/S phase of the cell cycle by cyclin expression. ( NCI )]
   UMLS (NCI) C1332697
   
   CCNE1 Gene
   Cyclin E1 Gene
    

   Gene or Genome