[Cyclin B1 is essential for control of the G2/M transition and the gene is expressed predominantly in the G2/M phase of cell division. Complexed with p34(cdc2), cyclin B1 forms mitosis-promoting factor (MPF), a serine/threonine kinase holoenzyme complex. Cyclin B1 imparts substrate specificity to MPF. Phosphorylation of cyclin B1 regulates nuclear translocation of MPF during prophase, essential for the induction and coordination of M-phase events. During cell cycle progression, a change in PLK1 kinase activity appears to phosphorylate cyclin B1 and stimulate nuclear entry of cyclin B1. (from SWISS-PROT P14635, OMIM 123836, and NCI) ( NCI )]
UMLS (NCI) C0385333 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
home 
Armenian-English 
top