[A murine anti-idiotypic monoclonal antibody (anti-Id MoAb) that directed against an idiotype mimicking a disialoganglioside GD3. GD3 represents a major surface marker on most human melanoma cells. Due to poor immunogenicity of GD3, anti-Id MoAb BEC2 (Ab2) was raised against a mouse anti-GD3 MoAb, R24 (Ab1). This anti-Id MoAb was shown to be functionally mimicking GD3 in stimulating immune response to produce Ab3 that maybe used in combination with other adjuvants for treatment of melanomas. ( NCI )]
UMLS (NCI) C0281550 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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