[A lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also circumvents multidrug-resistance (MDR) transporters, including p-glycoprotein. (NCI04) ( NCI )]
UMLS (NCI) C0214529 - Organic Chemical
- Pharmacologic Substance