A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
Aldosterone Receptor
[Highly expressed as 4 alternative isoforms in kidney and sweat glands by human NR3C2 Gene (NR3 Family), ubiquitous phosphorylated Mineralocorticoid Receptor contains an N-terminal modulating domain, a DNA-binding domain, and a C-terminal steroid (mineralocorticoid/glucocorticoid)-binding domain. Absent ligand, NR3C2 resides in a heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4 or with HSD11B2 in the ER membrane. Ligand-activated NR3C2 translocates to the nucleus, binds to DNA mineralocorticoid response elements as a homodimer or heterodimer with NR3C1, and transactivates target gene expression, which increases ion and water transport; raises extracellular fluid volume and blood pressure; and lowers potassium levels. NR3C2 appears to bind NCOA1, NCOA2, TIF1, and NRIP1. NR3C2 defects cause PHA1 and early onset hypertension. (NCI) ( NCI )]
UMLS (NCI) C0066563- Amino Acid, Peptide, or Protein
- Receptor
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