A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
Aldehyde Dehydrogenase 1 Family Member A2
[Encoded by human ALDH1A2 Gene, Aldehyde Dehydrogenase 1A2 (ADH Family) is a 499-amino acid 54.8 kD putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde. The protein contains conserved aldehyde dehydrogenase motifs: GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction. ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid. In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription. (OMIM, Swiss-Prot, and NCI) ( NCI )]
UMLS (NCI) C0752609Aldehyde Dehydrogenase 1 Family, Member A2
Aldehyde Dehydrogenase 1A2
ALDH1A2
RALDH(II)
RALDH2
RALDH-2
Retinaldehyde-Specific Dehydrogenase Type 2
Aldehyde Dehydrogenase 1A2
ALDH1A2
RALDH(II)
RALDH2
RALDH-2
Retinaldehyde-Specific Dehydrogenase Type 2
- Amino Acid, Peptide, or Protein
- Enzyme
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