A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
AT-Hook Protein
[Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81) ( NCI )]
UMLS (NCI) C0905617HMGA Family Protein
HMGI(Y) Protein
HMG-I(Y) Protein
HMG-I/Y Protein
HMG-I/Y/C
HMGI(Y) Protein
HMG-I(Y) Protein
HMG-I/Y Protein
HMG-I/Y/C
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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