- 1. AT Mutated
- [Ataxia Telangiectasia Mutated Protein, encoded by the ATM gene, belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates and functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, which results in a defect in cell cycle regulation and DNA repair. Mutations are also associated with sensitivity to DNA damaging agents such as ionizing radiation. At least 3 alternatively spliced transcript variants encoding distinct isoforms, have been identified. (from LocusLink) ( NCI )] (UMLS (NCI) C0298973) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 6. atmosphere
- [The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed) ( MSH )] (UMLS (CSP) C0004178) =Natural Phenomenon or Process ;
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- 2. atm
- [Non-SI unit of pressure equal to 101 325 Pa. ( NCI )] (UMLS (NCI) C0678214) =Quantitative Concept ;
=UnitOfMeasureAtomInsens;
UnitOfMeasureAtomSens | - 7. atmosphere (technical)
- [1 kgf/cm2 ( HL7V3.0 )] (UMLS (HL7) C1553014) =Quantitative Concept =UnitOfMeasureAtomInsens;
UnitOfMeasureAtomSens |
- 3. ATM Gene Mutation
- (UMLS (NCI) C1510697) =Cell or Molecular Dysfunction ;
| - 8. atmosphere/weather
- [gaseous envelope surrounding a planet or similar body including weather which is the state of the atmosphere at a given time and place, with respect to variables such as temperature, moisture, wind velocity, and barometric pressure. ( CSP )] (UMLS (CSP) C0935443) =Natural Phenomenon or Process ;
=environment;
=climate |
- 4. ATM Signaling Pathway
- [The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (Biocarta) ( NCI )] (UMLS (NCI) C1510698) =Molecular Function ;
| - 9. atmospheric pressure
- [pressure at any point in an atmosphere due solely to the weight of the atmospheric gases above the point concerned. ( CSP )] (UMLS (CSP) C0004180) =Natural Phenomenon or Process ;
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- 5. ATMOS PRESS/COMPOS CONTR
- [ ] (UMLS (ICD9CM) C0178051) =Therapeutic or Preventive Procedure
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