- 2. Atiprimod
- [An orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. ( NCI )] (UMLS (NCI) C0754307) N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine;
=Organic Chemical; Pharmacologic Substance | |