[Encoded by human ANGPT1 Gene, Angiopoietin-1 is a 498-amino acid 57.5 kD (precursor) secreted glycoprotein ligand for the endothelial TIE2 receptor tyrosine kinase and contains a predicted coiled-coil domain and a fibrinogen-like C-terminus. Its expression in endothelial and early hematopoietic cells suggests an action in vascular development. Antagonized by Angiopoietin-2, ANGPT1 structure differs from other angiogenic factors or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary for early stages of vascular development. ANGPT1 acts in vascular remodeling, maturation, and stability. ANGPT1 and TIE1 are critical for right side, but not left side, venous system development. (OMIM, Swiss-Prot, and NCI) ( NCI )]
UMLS (NCI) C0533670 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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