14-Hydroxydaunorubicin Hydrochloride

[The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects. ( NCI )]

UMLS (NCI) C0546861

Organic Chemical
Pharmacologic Substance

Relation/PAR: (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione

Relation/CHD: DOXORUBICIN HYDROCHLORIDE 10 MG
DOXORUBICIN HYDROCHLORIDE 100 MG
DOXORUBICIN HYDROCHLORIDE 150 MG
DOXORUBICIN HYDROCHLORIDE 2 MG/ML
DOXORUBICIN HYDROCHLORIDE 200 MG
DOXORUBICIN HYDROCHLORIDE 50 MG
DOXORUBICIN HYDROCHLORIDE 20 MG
DOXORUBICIN HYDROCHLORIDE 5 MG/ML

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