- 901. protein activity
- [ ] (UMLS (CSP) C1537044) =Molecular Function ;
| - 951. protein subunit
- [Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly. ( MSH )] (UMLS (CSP) C0599220) =Amino Acid, Peptide, or Protein
|
- 902. protein binding
- [strong physiochemical attraction between proteins and other molecules, including proteins. ( CSP )] (UMLS (CSP) C0033618) =Molecular Function =chemical binding;
=receptor binding | - 952. Protein Synthesis Inhibitor
- [Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. ( MSH )] (UMLS (NCI) C0033671) =Pharmacologic Substance =enzyme inhibitor;
|
- 903. protein biosynthesis
- [anabolic formation of proteins in organisms or living cells; for more specific steps in the process of forming proteins, see related terms. ( CSP )] (UMLS (CSP) C0597295) =Molecular Function =anabolism;
protein metabolism =enzyme biosynthesis;
glycoprotein biosynthesis;
hemoprotein biosynthesis;
| - 953. Protein Translation Factor SUI1 Homolog
- [Encoded by human SUI1 Gene (SUI1 Family), 113-aa 12.7-kDa Protein Translation Factor SUI1 Homolog is a putative negative growth regulator likely involved in translation. (NCI) ( NCI )] (UMLS (NCI) C0915260) Putative Translation Initiation Factor;
SUI1;
Sui1iso1;
Translation Initiation Factor 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 904. protein bound insulin
- [ ] (UMLS (CSP) C0597296) =Amino Acid, Peptide, or Protein
| - 954. protein transport
- [process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport; index with INTRACELLULAR TRANSPORT to differentiate intracellular from extracellular protein transport; do not confuse with TRANSPORT PROTEIN, a class of specific proteins. ( CSP )] (UMLS (CSP) C0599895) =Cell Function ;
=biological transport;
=Leader Sequence;
blood lipoprotein transport;
|
- 905. protein C
- [vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation. ( CSP )] (UMLS (CSP) C0033621) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance =blood protein;
| - 955. Protein Tyrosine Kinase 3
- [Widely expressed (abundant in brain) by human TYRO3 Gene (AXL/UFO Tyr Kinase Family), 890-aa 97-kDa (precursor) type I membrane protein TYRO3 Protein Tyrosine Kinase is a putative receptor tyrosine kinase that may be involved in cell adhesion in the central nervous system and contains 2 Ig-like C2-type domains and 2 fibronectin type III domains. (NCI) ( NCI )] (UMLS (NCI) C0252032) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 906. Protein Cleavage
- [splitting of proteins by hydrolysis of the peptide bonds with formation of smaller polypeptides; the process may be catalyzed by proteolytic enzymes, by acids, or by bases. ( CSP )] (UMLS (NCI) C0597304) =Molecular Function =protein degradation;
| - 956. Protein Tyrosine Kinase Inhibitor Therapy
- (UMLS (NCI) C0879484) =Therapeutic or Preventive Procedure
|
- 907. Protein Complex Subunit
- [Used for classifying a protein or peptide that does not have a perceptible function before it is assembled into a functional complex. ( NCI )] (UMLS (NCI) C1335530) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 957. Protein Tyrosine Kinase Inhibitors
- [A family of drugs that interfere with cell communication and may prevent tumor growth. They are being studied as a treatment for cancer. ( NCI )] (UMLS (NCI) C1268567) PTK Inhibitors;
TK Inhibitors;
Tyrosine Kinase Inhibitor;
tyrosine kinase inhibitors =Pharmacologic Substance; ;
|
- 908. Protein Complex Subunit Gene
- [A gene that encodes a protein product that is a component of a larger protein agglomeration or complex. The gene product can be an assembly component of a functional protein complex or a factor involved in stabilization. ( NCI )] (UMLS (NCI) C1335531) =Gene or Genome ;
| - 958. Protein Tyrosine Phosphatase 2C
- [Phosphatase involved in apoptosis regulation in multiple myeloma. Normally activated by IL-6, it regulates the activity of RAFT Kinase ( NCI )] (UMLS (NCI) C0656342) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 909. protein database
- [DATABASES containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties. ( MSH )] (UMLS (CSP) C0872249) =Intellectual Product
| - 959. Protein Tyrosine Phosphatase G1
- [Encoded by human PTPN12 Gene (Non-Receptor PTP Family), 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase contains a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI) ( NCI )] (UMLS (NCI) C0255873) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 910. PROTEIN DEFIC ANEMIA
- [ ] (UMLS (ICD9CM) C0154290) =Disease or Syndrome
| - 960. Protein Tyrosine Phosphatase Gene
- [Protein Tyrosine Phosphatase Genes encode Protein Tyrosine Phosphatases, enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI) ( NCI )] (UMLS (NCI) C1335554) PTP Family Gene;
Receptor Type PTP Gene;
=Gene or Genome ;
|
- 911. protein deficiency
- [nutritional condition produced by a deficiency of proteins in the diet; growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency; protein deficiency may also arise in the face of adequate protein intake if the dietary protein is inadequate in one or more aminoacids. ( CSP )] (UMLS (CSP) C0033626) =Disease or Syndrome =Deficiency Diseases;
dietary deficiency =Protein Energy Malnutrition | - 961. Protein Tyrosine Phosphatase Type IVA, Member 1 Gene
- [This gene is involved in liver cell growth and the cellular response to mitogens. ( NCI )] (UMLS (NCI) C1419089) PTP4A1;
PTP4A1 Gene =Gene or Genome |
- 912. protein degradation
- [normal "downside" of protein steady state metabolism in cells, involving conjugation, transport, oxidation, and proteolysis; do not confuse with PROTEOLYSIS, which applies only to peptide bond hydrolysis. ( CSP )] (UMLS (CSP) C1623036) Protein Degradation, Regulatory =Molecular Function ;
=protein metabolism;
=protein denaturation;
Protein Cleavage;
| - 962. Protein Tyrosine Phosphatase, Non-Receptor Type 1
- [Encoded by human PTPN1 Gene (Non-Receptor PTP Family), 435-aa 50-kDa Non-Receptor Type 1 Protein Tyrosine Phosphatase is a negative regulator of insulin signaling by dephosphorylating insulin receptor kinase and is associated with the endoplasmic reticulum via its C-terminal domain and its phosphatase domain oriented towards the cytoplasm. PTPN1 may also dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Protein Tyrosine Phosphatases typically regulate cellular processes such as cell growth, differentiation, and mitotic cycle. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (NCI) ( NCI )] (UMLS (NCI) C1335056) PTPN1;
=Amino Acid, Peptide, or Protein; Enzyme |
- 913. Protein Degradation
- [The normal "downside" of protein steady state metabolism in cells, involving conjugation, transport, oxidation, and proteolysis; not to be confuse with proteolysis, which applies only to peptide bond hydrolysis. ( NCI )] (UMLS (NCI) C0597297) =Molecular Function
| - 963. Protein Tyrosine Phosphatase, Non-Receptor Type 1 Gene
- [This gene plays a role in the regulation of insulin signaling and inhibition of cell growth. ( NCI )] (UMLS (NCI) C1335281) PTPN1;
PTPN1 Gene =Gene or Genome |
- 914. protein denaturation
- [process of unfolding or otherwise grossly changing the tertiary structure of a protein; usually applies to experimental treatments, although may occur in biological contexts (e.g., "heat shock"). ( CSP )] (UMLS (CSP) C0033627) =Molecular Function =protein structure;
protein degradation | - 964. Protein Tyrosine Phosphatase, Non-Receptor Type 11 (Noonan Syndrome 1) Gene
- [This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene transcription. ( NCI )] (UMLS (NCI) C1335280) PTPN11;
PTPN11 Gene =Gene or Genome |
- 915. protein distribution
- [ ] (UMLS (CSP) C0872250) =Cell Function
| - 965. Protein Tyrosine Phosphatase, Non-Receptor Type 12 Gene
- [This gene plays a role in the regulation of cell shape and mobility. ( NCI )] (UMLS (NCI) C1368803) PTPN12;
PTPN12 Gene =Gene or Genome |
- 916. Protein Energy Malnutrition
- [The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses. ( MSH )] (UMLS (NCI) C0033677) =Pathologic Function =protein deficiency;
=KWASHIORKOR | - 966. Protein Tyrosine Phosphatase, Non-Receptor Type 22
- [Predominantly expressed in lymphoid tissues as distinct alternative isoforms by human PTPN22 Gene (Non-Receptor PTP Family), Non-Receptor Type 22 Protein Tyrosine Phosphatase associates with and appears to regulate adapter protein CBL function and its associated protein kinases in the T-cell receptor signaling pathway. (NCI) ( NCI )] (UMLS (NCI) C1335057) PTPN22;
=Amino Acid, Peptide, or Protein; Enzyme |
- 917. protein engineering
- [experimental or other man-made manipulations resulting in proteins which do not occur in nature; frequently, but not always, involves genetic manipulation. ( CSP )] (UMLS (CSP) C0033629) =Laboratory Procedure; Molecular Biology Research Technique ;
=biotechnology;
| - 967. Protein Tyrosine Phosphatase, Non-Receptor Type 22 (Lymphoid) Gene
- [This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens. ( NCI )] (UMLS (NCI) C1419102) PTPN22;
PTPN22 Gene =Gene or Genome |
- 918. Protein Expression Profiling
- (UMLS (NCI) C1327760) Proteomic Profiling;
=Diagnostic Procedure; ;
| - 968. Protein Tyrosine Phosphatase, Non-Receptor Type 6 Gene
- [This gene plays a role in the regulation of multiple signaling pathways in hematopoietic cells. ( NCI )] (UMLS (NCI) C1335283) PTPN6;
PTPN6 Gene =Gene or Genome |
- 919. Protein Family
- [Collection of proteins that are evolutionarily related. This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP) ( NCI )] (UMLS (NCI) C1335532) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 969. Protein Tyrosine Phosphatase, Non-Receptor Type 7 Gene
- [This gene plays a role in regulation of lymphocyte development and suppression of signal transduction. ( NCI )] (UMLS (NCI) C1335284) PTPN7;
PTPN7 Gene =Gene or Genome |
- 920. Protein Folding
- [process by which polypeptide chains assume their three-dimensional conformation, either during normal protein biosynthesis or experimental protein reconstitution. ( CSP )] (UMLS (NCI) C0162847) =Molecular Function ;
=protein structure;
| - 970. Protein Tyrosine Phosphatase, Receptor Type, C Gene
- [This gene plays a role in suppression of cytokine receptor signaling and the regulation of signal transduction in lymphocytes. ( NCI )] (UMLS (NCI) C1335285) PTPRC;
PTPRC Gene =Gene or Genome |
- 921. Protein Fragment
- [A fragment of a protein, which may be a diagnostic or prognostic factor and used as a biomarker. (NCI) ( NCI )] (UMLS (NCI) C1335533) =Amino Acid, Peptide, or Protein; Indicator, Reagent, or Diagnostic Aid
| - 971. Protein Tyrosine Phosphatase, Receptor Type, E Gene
- [This gene is involved in regulation of signal transduction and inhibition of the cellular response to mitogens. ( NCI )] (UMLS (NCI) C1335286) PTPRE;
PTPRE Gene =Gene or Genome |
- 922. protein function
- [The action of enzymes, regulators, chaperones etc. ( NCI )] (UMLS (CSP) C1527118) =Molecular Function; ;
| - 972. Protein Tyrosine Phosphatase, Receptor Type, G Gene
- [This gene plays a role in the regulation of cell growth, differentiation, mitosis, and malignant transformation. ( NCI )] (UMLS (NCI) C1335287) PTPRG;
PTPRG Gene =Gene or Genome |
- 923. protein glutamine gamma glutamyltransferase
- [Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence. ( MSH )] (UMLS (CSP) C0033679) =Amino Acid, Peptide, or Protein; Enzyme ;
=glutamyltransferase;
| - 973. Protein Tyrosine Phosphatase, Receptor Type, J Gene
- [This gene plays a role in the negative regulation of T cell receptor signaling. ( NCI )] (UMLS (NCI) C1335288) PTPRJ;
PTPRJ Gene =Gene or Genome ;
|
- 924. Protein Hormone Receptor
- [Typically associated with the cell membrane, Protein Hormone Receptors selectively bind with high affinity to genetically-encoded polymerized amino acids in peptide linkage that have regulatory effects on the activity of specific target cells. A ligand-induced conformational and functional change in the receptor alters its interaction with target molecules, leading to changes in cellular physiology through modification of the activity of signal transduction pathways. ( NCI )] (UMLS (NCI) C1335534) =Amino Acid, Peptide, or Protein; Receptor ;
| - 974. Protein Tyrosine Phosphatase, Receptor Type, R Gene
- [This gene is involved in neuronal growth and differentiation. ( NCI )] (UMLS (NCI) C1419123) PTPRR;
PTPRR Gene =Gene or Genome |
- 925. Protein Import
- [Protein Import involves active cellular mechanisms that directly promote the transport of a protein across the plasma membrane into a cell. ( NCI )] (UMLS (NCI) C1326471) =Cell Function
| - 975. Protein Tyrosine Phosphatase, Receptor Type, T Gene
- [This gene plays a role in the control of motor axon guidance. ( NCI )] (UMLS (NCI) C1335289) PTPRT;
PTPRT Gene =Gene or Genome ;
|
- 926. Protein Kinase A Inhibitor
- [Substances that inhibit the action of Protein Kinase A, causing disruption of a protein phosphorylation cascade in certain signal transduction pathways. ( NCI )] (UMLS (NCI) C0243459) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
| - 976. Protein, Organized by Function
- [Organizing term for the Proteins tree ( NCI )] (UMLS (NCI) C0815043) Proteins [By Function];
=Amino Acid, Peptide, or Protein ;
|
- 927. Protein Kinase Inhibitor
- [Substances that inhibit the protein phosphorylation in the signaling pathway, which regulates a variety of fundamental processes, such as cell growth, mitogenesis, metabolism, gene transcription, cell cycle control, and the immune response. (NCI) ( NCI )] (UMLS (NCI) C1449702) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
| - 977. Protein, Organized by Location
- [Organizing term for the Proteins tree ( NCI )] (UMLS (NCI) C1367806) Proteins [By Location];
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 928. protein kinase R
- [ ] (UMLS (CSP) C0872251) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 978. Protein, Organized by Origin
- [Organizing term for the Proteins tree ( NCI )] (UMLS (NCI) C1335535) Proteins [By Origin];
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 929. Protein L1, Type 16 Human Papillomavirus
- [A papillomavirus capsid protein ( NCI )] (UMLS (NCI) C0083858) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 979. Protein, Organized by Structure
- [Organizing term for the Proteins tree ( NCI )] (UMLS (NCI) C0175168) =Classification ;
|
- 930. protein localization
- [determination of where in an organism (i.e., organ system) or cell (i.e., organelle) a specific protein may be found. ( CSP )] (UMLS (CSP) C0597704) =Cell Function ;
=protein metabolism;
| - 980. Proteinase 3 (Serine Proteinase, Neutrophil, Wegener Granulomatosis Autoantigen) Gene
- [This gene plays a role in the growth of hematopoietic cells. ( NCI )] (UMLS (NCI) C1335267) PRTN3;
PRTN3 Gene =Gene or Genome |
- 931. protein mechanism of action
- [ ] (UMLS (CSP) C1537045) =Molecular Function ;
| - 981. Proteinase Inhibitor Gene
- [Proteinase Inhibitor Genes encode Proteinase Inhibitor Proteins that block the activity of proteases, endopeptidases that catalyze the cleavage of internal peptide bonds in a polypeptide or protein substrate (Serine Endopeptidases, Cysteine Endopeptidases, Aspartic Endopeptidases, Metalloendopeptidases, and other Endopeptidases). (NCI) ( NCI )] (UMLS (NCI) C1335559) =Gene or Genome ;
|
- 932. protein metabolism
- [sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of proteins; the buildup and breakdown of proteins for utilization by the organism. ( CSP )] (UMLS (CSP) C0597299) =Molecular Function =Intermediary Metabolism;
=Post Translational Modification;
blood lipoprotein metabolism;
hemoprotein metabolism;
protein biosynthesis;
protein localization;
protein degradation | - 982. proteinuria
- [presence of excess protein in the urine. ( CSP )] (UMLS (CSP) C0033687) =Disease or Syndrome =Clinical Finding;
RENAL AND URINARY DISORDERS =albuminuria;
hemoglobinuria;
albuminuria |
- 933. protein metabolism disorder
- [condition in which there is a deviation or interruption in the processing of proteins in the body: synthesis, absorption, transport, storage, and utilization. ( CSP )] (UMLS (CSP) C0597300) =Disease or Syndrome =Metabolic Disease;
=hypoproteinemia;
gammopathy;
hyperproteinemia;
| - 983. proteoglycan
- [family of glycoproteins with repeating disaccharide subunits, including the mucopolysaccharide glycoproteins (mucoproteins), and found in extracellular matrix. ( CSP )] (UMLS (NCI) C0033692) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=glycoprotein;
Extracellular Matrix Protein =decorin;
link protein;
syndecan |
- 934. Protein Microarray
- [A molecular biology device consisting of a set of defined proteins, protein fragments, or peptides attached in a specific grid arrangement to a solid support. ( NCI )] (UMLS (NCI) C1136348) =Medical Device; Research Device ;
| - 984. proteolipid
- [covalent complexes of protein and lipid with lipophilic properties; LIPOPROTEIN, by contrast, can be noncovalent and water soluble, but in modern usage both terms are applied to membrane proteolipids. ( CSP )] (UMLS (CSP) C0033693) =Amino Acid, Peptide, or Protein; Lipid; Biologically Active Substance =gene product;
=myelin proteolipid |
- 935. Protein or Riboprotein Complex
- [Multimeric subcellular structures containing proteins, and possibly, RNA. ( NCI )] (UMLS (NCI) C1335557) =Amino Acid, Peptide, or Protein ;
| - 985. Proteome
- [In its most basic sense the term proteome refer to the total protein-encoding capability of an organism's genome. It is also used to refer to the actual total expressed protein complement of an organism or to the identifiable proteins of a single tissue or cell type or subcellular compartment. ( NCI )] (UMLS (NCI) C0751973) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 936. Protein Phosphatase 2A Subunit Gene
- [The Protein Phosphatase 2A Subunit Genes encodes 3 subunits (A, B, and C) of Protein Phosphatase 2A (PP2A) holoenzyme, a heterotrimeric serine/threonine phosphatase. The structural A subunit and the catalytic C subunit form a catalytic core, while substrate specificity is directed by the B subunit. PP2A exerts regulatory control over the initiation of DNA replication and has a particularly complex set of regulatory subunits controlling its function and localization. ( NCI )] (UMLS (NCI) C1335538) =Gene or Genome; ;
| - 986. proteomics
- [field that utilizes protein sequences, expression and structure to determine how proteins relate, interact and function in an organism; includes characterizing and cataloguing proteins and protein libraries, comparing variations in protein expression levels under different conditions, studying protein interactions and functional roles; techniques are performed in an automated, large scale manner; may also involve bioinformatic analysis and storage of data. ( CSP )] (UMLS (CSP) C0872252) =Biomedical Occupation or Discipline ;
=Molecular Biology;
|
- 937. Protein Phosphatase Gene
- [Protein Phosphatase Genes encode Protein Phosphatases, enzymes that remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI) ( NCI )] (UMLS (NCI) C1335547) =Gene or Genome; ;
| - 987. Protestant
- (UMLS (HL7) C0242220) =Population Group ;
=Religious Affiliation;
|
- 938. Protein Phosphatase Regulatory Protein
- [Protein Phosphatase Regulatory Proteins are constant regulatory/scaffolding subunits of PP2 that coordinate assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )] (UMLS (NCI) C1335548) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 988. Protestant, No Denomination
- (UMLS (HL7) C1698516) =Population Group ;
=Religious Affiliation;
|
- 939. protein protein interaction
- [interaction among or within protein domains which may alter the structure thus affecting the function of the protein or group of proteins. ( CSP )] (UMLS (CSP) C0872079) Protein-Protein Interaction;
=Molecular Function ;
=intermolecular interaction;
protein structure function | - 989. Proteus
- [genus of gram negative, facultatively anaerobic, rod shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters; its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body. ( CSP )] (UMLS (CSP) C0033697) =Bacterium ;
=coliform bacilli;
|
- 940. protein purification
- [isolation and purification of proteins; may be separated by isoelectric points, size or molecular weight, or according to their unique binding properties. ( CSP )] (UMLS (CSP) C0597301) =Laboratory Procedure =physical separation;
| - 990. Proteus (mirabilis) (morganii) infection in conditions classified elsewhere and of unspecified site
- (UMLS (ICD9CM) C0033698) =Disease or Syndrome ;
|
- 941. protein quantitation/detection
- [the study of proteins that are present or expressed, along with their relative abundance, in various cells and tissues over time and under specific conditions such as comparisons between diseased and normal tissue. ( CSP )] (UMLS (CSP) C1171314) =Laboratory Procedure ;
=analytical method;
| - 991. Proteus infection
- [Infections with bacteria of the genus PROTEUS. ( MSH )] (UMLS (CSP) C0033700) =Disease or Syndrome ;
=Enterobacteriaceae disease;
|
- 942. protein reconstitution
- [returning of denatured protein to its original structure and activity; an unfolded polypeptide chain returning to its normal folded three-dimensional structure. ( CSP )] (UMLS (CSP) C0597302) =Molecular Function =protein structure;
=enzyme reconstitution;
| - 992. Prothromadin
- [The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. ( NCI )] (UMLS (NCI) C0376218) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone;
=WARFARIN SODIUM 1 MG;
WARFARIN SODIUM 2 MG;
WARFARIN SODIUM 2.5 MG;
WARFARIN SODIUM 4 MG;
WARFARIN SODIUM 10 MG;
WARFARIN SODIUM 3 MG;
WARFARIN SODIUM 6 MG;
WARFARIN SODIUM 7.5 MG;
WARFARIN SODIUM 50 MG;
WARFARIN SODIUM 5 MG;
|
- 943. Protein Renaturation
- [The process of restoring the activity and quaternary structure of a native polypeptide through folding and conformational intermediates. ( NCI )] (UMLS (NCI) C0599210) =Phenomenon or Process ;
| - 993. prothrombase
- [Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors. ( MSH )] (UMLS (CSP) C0015520) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 944. protein S
- [vitamin K-dependent cofactor of activated protein C; a deficiency can lead to recurrent venous and arterial thrombosis. ( CSP )] (UMLS (CSP) C0072393) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=[BL600] THROMBOLYTICS;
| - 994. prothrombin activator
- [ ] (UMLS (CSP) C0599536) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 945. Protein Secretion
- [Vectorial transport of proteins across a cell membrane to the extracellular environment. ( NCI )] (UMLS (NCI) C1159339) =Cell Function
| - 995. prothrombin time
- [clotting time of plasma recalcified in the presence of excess tissue thromboplastin; used for monitoring anticoagulant therapy with coumarins. ( CSP )] (UMLS (CSP) C0033707) =Laboratory Procedure ;
=blood coagulation test;
|
- 946. Protein Serine/Threonine Phosphatase
- [Encoded by Protein Serine/Threonine Phosphatase Genes, Protein Serine/Threonine Phosphatases are a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. ( NCI )] (UMLS (NCI) C0084210) =Amino Acid, Peptide, or Protein; Enzyme
| - 996. Prothymosin L
- (UMLS (NCI) C1335560) =Amino Acid, Peptide, or Protein; Hormone
|
- 947. Protein Serine/Threonine Phosphatase Gene
- [Protein Serine/Threonine Phosphatase Genes encode Protein Serine/Threonine Phosphatases, a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI) ( NCI )] (UMLS (NCI) C1335550) Serine/Threonine-Specific Protein Phosphatase Gene =Gene or Genome; ;
| - 997. Prothymosin, Alpha (Gene Sequence 28) Gene
- [This gene is involved in the mediation of immune function. ( NCI )] (UMLS (NCI) C1419080) PTMA;
PTMA Gene =Gene or Genome |
- 948. Protein Splicing
- [Excision of in-frame internal protein sequences (inteins) of a precursor protein, coupled with ligation of the flanking sequences (exteins). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein. ( NCI )] (UMLS (NCI) C0376437) =Genetic Function ;
| - 998. PROTIRELIN
- [tripeptide hormone elaborated by the median eminence of the hypothalamus which stimulates release of thyrotropin from the anterior pituitary gland. ( CSP )] (UMLS (NCI) C0040162) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine; Hormone =Hypothalamic Hormone;
neuropeptide;
oligopeptide;
[DX900] DIAGNOSTICS, OTHER =PROTIRELIN 0.5 MG/ML |
- 949. protein structure
- [characteristic shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain, as well as the number, type and location of bonds. ( CSP )] (UMLS (CSP) C1510464) =Amino Acid, Peptide, or Protein ;
=chemical structure;
=amino acid sequence;
[IM500] IMMUNOGLOBULINS;
protein denaturation;
Leader Sequence;
Protein Folding;
globular protein;
enzyme structure;
glycoprotein structure;
hemoprotein structure;
protein reconstitution | - 999. Protista
- [single celled eukaryotic organisms having plant, animal, or fungal characteristics; have highly developed cell organelles; freeliving; heterotrophic, autotrophic, and saprophytic; terrestrial or aquatic. ( CSP )] (UMLS (CSP) C0597305) =Organism =microorganism;
=Dinoflagellate;
Euglena;
protozoa;
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- 950. protein structure function
- [protein structure as it relates to its function. ( CSP )] (UMLS (CSP) C0597303) =Chemical Viewed Functionally =chemical structure function;
=enzyme activity;
enzyme mechanism;
protein protein interaction;
| - 1000. Proto-Oncogene, Signaling Factor
- [Signaling Pathway Genes encode proteins or peptides that participate in intracellular signal transduction processes. ( NCI )] (UMLS (NCI) C0935996) Signaling Pathway Gene =Gene or Genome
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