[The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. ( NCI )]
UMLS (NCI) C0376218 - Organic Chemical
- Pharmacologic Substance
- Hazardous or Poisonous Substance
Relation/PAR: 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
Relation/CHD: WARFARIN SODIUM 1 MG
WARFARIN SODIUM 2 MG
WARFARIN SODIUM 2.5 MG
WARFARIN SODIUM 4 MG
WARFARIN SODIUM 10 MG
WARFARIN SODIUM 3 MG
WARFARIN SODIUM 6 MG
WARFARIN SODIUM 7.5 MG
WARFARIN SODIUM 50 MG
WARFARIN SODIUM 5 MG