[The hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramoxine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and , thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade. ( NCI )] (UMLS (NCI) C0147008) =Organic Chemical; Pharmacologic Substance =pramocaine; =PRAMOXINE HYDROCHLORIDE 1 %WW; PRAMOXINE HYDROCHLORIDE 10 MG/GM; PRAMOXINE HYDROCHLORIDE 0.1 %; PRAMOXINE HYDROCHLORIDE 0.5 %; PRAMOXINE HYDROCHLORIDE 1 %