[The hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramoxine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and , thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade. ( NCI )]
UMLS (NCI) C0147008 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: pramocaine
Relation/CHD: PRAMOXINE HYDROCHLORIDE 1 %WW
PRAMOXINE HYDROCHLORIDE 10 MG/GM
PRAMOXINE HYDROCHLORIDE 0.1 %
PRAMOXINE HYDROCHLORIDE 0.5 %
PRAMOXINE HYDROCHLORIDE 1 %