- 1. 130 kDa Retinoblastoma-Associated Protein
- [Expressed only in G0 by human RBL2 Gene (RB Family), 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI) ( NCI )] (UMLS (NCI) C0249759) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 10. 70 kDa Ribosomal Protein S6 Kinase 2
- [Encoded by human RPS6KB2 Gene (S6 Ser/Thr Kinase Family), 482-aa 53-kDa Ribosomal Protein S6 Kinase Beta 2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes. (NCI) ( NCI )] (UMLS (NCI) C1138418) p70 Ribosomal S6 Kinase Beta;
p70 S6K Beta;
p70-Beta;
p70S6KB;
p70-S6KB;
Ribosomal Protein S6 Kinase Beta 2;
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2;
RPS6KB2;
S6 Kinase-Related Kinase;
S6K2;
S6K-Beta 2;
Serine/Threonine-Protein Kinase 14 Beta;
SRK =Amino Acid, Peptide, or Protein; Enzyme |
- 2. 150 kD Oxygen-Regulated Protein
- [Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein is an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI) ( NCI )] (UMLS (NCI) C0377954) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 11. 70-kD Heat Shock Protein
- [Heat Shock Protein 70 is a class of conserved molecular chaperone proteins in both prokaryotes and eukaryotic cells that may interact with polypeptides during the assembly processes to prevent the formation of nonfunctional structures. There are at least three HSP70 loci in the human genome, which map to chromosomes 6, 14, 21, and at least one other chromosome. Heat-shock proteins are expressed in response to a variety of stresses. The human HSP70 multi-gene family encodes highly conserved 70 kD proteins with structural and functional properties in common, but which vary in their response to metabolic stress. Some mRNAs are rapidly degraded through an AU-rich 3-prime untranslated region bound by AUF1, which complexes with HSC70, HSP70, EIF4G, and poly(A)-binding protein. The mRNA decay is associated with displacement of EIF4G from AUF1, ubiquitination of AUF1, and degradation. HSP70 blocks decay of AU-rich mRNAs and AUF1 protein. ( NCI )] (UMLS (NCI) C0243043) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 3. 170-kD Melanoma Membrane-Bound Gelatinase
- [Expressed in fibroblasts similar to DPP4 and DPPX, inducible Fibroblast Activation Protein-Alpha major isoform 1 (Long, 760-aa, 87.8-kD) and truncated isoform 2 (Short, 239-aa) are encoded by human FAP Gene (Peptidase S9B Family). Heterodimeric (with DPP4) or homodimeric, N-glycosylated FAPA is a type II integral membrane protein gelatinase: 13 extracellular cysteine residues and 3 conserved serine protease domains, a transmembrane segment, and a short cytoplasmic tail. Monomer is inactive. On lamellipodia, FAPA appears involved in epithelial-mesenchymal interactions during development, tissue repair/remodeling, epithelial carcinogenesis, and malignant invasion. A product of the same gene, monomeric N-glycosylated Seprase is composed of proteolytically inactive subunits whose activities depend on subunit association. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0290024) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
| - 12. 70-kD Heat-Shock Protein/MUC-1 Antigen
- [A fusion protein of the MUC-1 colorectal cancer surface marker with HSP70 as a carrier. In trials as a cancer vaccine. ( NCI )] (UMLS (NCI) C0392929) =Therapeutic or Preventive Procedure ;
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- 4. 21-kDa TBP-Like Protein
- [Ubiquitously expressed (highest in testis and brain) human TBPL1 Gene (TBP Family), encodes 186-aa 21-kDa DNA-binding TBP-Like Protein 1, which serves the same function as TBP, substituting for TBP at some promoters not recognized by TFIID. TBPL1 binds TFIIA and TFIIB, does not bind the TATA box, may be important in expression of some developmentally regulated genes, and is essential for spermiogenesis. (NCI) ( NCI )] (UMLS (NCI) C1336592) STUD Protein;
TATA Box Binding Protein-Like Protein 1;
TATA Box Binding Protein-Related Factor 2;
TBP-Like Protein 1;
TBP-Related Factor 2;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 13. 72kD type IV Collagenase
- [Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (from LocusLink) ( NCI )] (UMLS (NCI) C0172537) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 5. 28 kDa Heat Shock Protein
- [Heat-shock proteins belong to a large group stress proteins, induced in response to environmental challenges and developmental transitions. Involved in stress resistance and actin organization, synthesis of HSP27 is correlated with the acquisition of thermotolerance. HSP27 belongs to the HSP20 family and shows sequence similarity to alpha-crystallins. Cytoplasmic HSP27 associates with alpha- and beta-tubulin, and with interphase and mitotic microtubules. HSP27 translocates to the nucleus during heat shock and is phosphorylated on exposure to PKC activators and heat shock. (from OMIM 602195, Swiss-Prot P04792, and NCI) ( NCI )] (UMLS (NCI) C1447061) Estrogen-regulated 24 kDa Protein;
Heat Shock 27 kD Protein 1;
Heat Shock Protein 27;
HSPB1;
Stress-responsive Protein 27;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 14. 76 kD Tyrosine Phosphoprotein
- [Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0296250) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 6. 33kDa Phototransducing Protein
- [Phosducin, encoded by the PDC gene, is a phosphoprotein that is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. (from LocusLink) ( NCI )] (UMLS (NCI) C0084024) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 15. 90 kDa Ribosomal Protein S6 Kinase 5
- [Widely expressed in heart, brain, placenta, lung, kidney, and liver by human RPS6KA5 Gene (S6 Ser/Thr Kinase Family), predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5 is a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI) ( NCI )] (UMLS (NCI) C0913240) Mitogen- and Stress-Activated Protein Kinase 1;
Nuclear Mitogen-and Stress-Activated Protein Kinase-1;
Ribosomal Protein S6 Kinase 90kD Polypeptide 5;
Ribosomal Protein S6 Kinase Alpha 5;
RLSK;
RPS6KA5;
RSK-Like Protein Kinase;
=Amino Acid, Peptide, or Protein; Enzyme ;
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- 7. 34/67 kD Laminin Receptor
- [Encoded by human LAMR1 Gene (Non-Integrin Family, S2P Family), this 295-amino acid 37-kD protein contains a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. Identical to 40S Ribosomal Protein SA, the heterodimeric 67-kD Laminin Receptor-1 is a conserved multifunctional protein involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Expression in cancer cells correlates with invasive/metastatic phenotype. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1367780) 37LRP;
40S Ribosomal Protein SA;
67kD Laminin Receptor;
67kD, Ribosomal Protein SA;
67LR;
Colon Carcinoma Laminin-Binding Protein;
Laminin Receptor;
Laminin Receptor 1;
Laminin Receptor 1 (67kD, Ribosomal Protein SA);
Laminin Receptor 1 (Ribosomal Protein SA, 67kD);
Laminin Receptor, 67-kD;
Laminin Receptor-1;
Laminin Receptor-1 (67kD);
Laminin Receptor-1, 40S Ribosomal Protein SA;
LAMR1;
LAMR1 Protein;
Multidrug Resistance-Associated Protein MGR1-AG;
NEM/1CHD4;
p40;
p40 Ribosome-Associated Protein;
Ribosomal Protein SA =Amino Acid, Peptide, or Protein; Receptor | - 16. 95 kDa Melanocyte-Specific Secreted Glycoprotein
- [Expressed in melanocytes and melanomas by human SILV Gene (PMEL17/NMB Family), 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100is a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. (NCI) ( NCI )] (UMLS (NCI) C0257766) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 8. 350/400 kDa PCAF-Associated Factor
- [Encoded by human TRRAP Gene (TRA1 Kinase Family), 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats, are a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI) ( NCI )] (UMLS (NCI) C1336800) PAF350/400;
STAF40;
TRA1 Homologue;
Transformation/Transcription Domain-Associated Protein;
TRRAP;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 17. 98 kD Nucleoporin
- [Encoded by human NUP98 Gene (GLFG Nucleoporin Family), 937-amino acid Nucleoporin 98 kD (NUP98) is up regulated by interferon and generated through proteolytic cleavage of a 186 kD precursor yielding NUP98 and NUP96, both associated with the nuclear pore complex (NPC). NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA. NUP98 likely functions as an import docking protein. The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease. NUP98 docking/transport function is localized to N-terminal GLFG/FXFG repeats. mRNA nuclear export inhibition by Vesicular Stomatitis Virus M Protein targets NUP98. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0297065) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 9. 55 kDa Erythrocyte Membrane Protein
- [Expressed in a variety of tissues (abundantly in erythroid stem cells to differentiated reticulocytes) by human MPP1 Gene (MAGUK Family), 466-aa 52-kDa Palmitoylated Membrane Protein 1 contains 1 PDZ/DHR domain, 1 conserved SH3 domain, 1 guanylate kinase-like domain, and a region that binds to cytoskeletal protein 4.1. Tightly associated with the plasma membrane and extensively palmitoylated, MPP1 interacts with DLG5 and is suspected to play a role in signal transduction. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI) ( NCI )] (UMLS (NCI) C1335296) EMP55;
Erythrocyte Membrane Protein p55;
p55;
Palmitoylated Membrane Protein 1;
Palmitoylated Membrane Protein 1 55kD;
PEMP =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 18. KDR
- [This gene plays a role in angiogenesis and vascular regulation. ( NCI )] (UMLS (NCI) C1334306) KDR Gene;
Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase) Gene;
=Gene or Genome |
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