170-kD Melanoma Membrane-Bound Gelatinase
[Expressed in fibroblasts similar to DPP4 and DPPX, inducible Fibroblast Activation Protein-Alpha major isoform 1 (Long, 760-aa, 87.8-kD) and truncated isoform 2 (Short, 239-aa) are encoded by human FAP Gene (Peptidase S9B Family). Heterodimeric (with DPP4) or homodimeric, N-glycosylated FAPA is a type II integral membrane protein gelatinase: 13 extracellular cysteine residues and 3 conserved serine protease domains, a transmembrane segment, and a short cytoplasmic tail. Monomer is inactive. On lamellipodia, FAPA appears involved in epithelial-mesenchymal interactions during development, tissue repair/remodeling, epithelial carcinogenesis, and malignant invasion. A product of the same gene, monomeric N-glycosylated Seprase is composed of proteolytically inactive subunits whose activities depend on subunit association. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0290024- Amino Acid, Peptide, or Protein
- Enzyme
- Receptor
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
