98 kD Nucleoporin
[Encoded by human NUP98 Gene (GLFG Nucleoporin Family), 937-amino acid Nucleoporin 98 kD (NUP98) is up regulated by interferon and generated through proteolytic cleavage of a 186 kD precursor yielding NUP98 and NUP96, both associated with the nuclear pore complex (NPC). NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA. NUP98 likely functions as an import docking protein. The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease. NUP98 docking/transport function is localized to N-terminal GLFG/FXFG repeats. mRNA nuclear export inhibition by Vesicular Stomatitis Virus M Protein targets NUP98. (from Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0297065- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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