FLT4 Ligand
[Encoded by human VEGFC Gene (PDGF/VEGF Family), VEGFC is expressed in spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon, and small intestine, as well as fetal liver, lung, and kidney. Active in angiogenesis, endothelial growth, and vascular permeability, VEGFC may maintain adult lymphatic endothelium. A FLT4 ligand, VEGFC is a 419-amino acid 47 kD (precursor) disulfide-linked homodimeric secreted polypeptide with C-terminal cysteine-rich BR3P repeats and similar to VEGF and VEGFB/VRF. VEGFC can also activate endothelial VEGFR2 (KDR/FLK1). VEGFC proteolytic maturation generates isoforms with increased VEGFR3 activity; fully processed VEGFC activates VEGFR2. Mature VEGFC is mostly composed of two VEGF homology domains bound by non-covalent interactions. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )]
UMLS (NCI) C0388911- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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