- 1. FJ 776
- (UMLS (NCI) C0386287) =Organic Chemical; Pharmacologic Substance ;
| - 2. FJ5002
- [A derivative of rhodacyanine with potential antineoplastic activity. FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells. Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04) ( NCI )] (UMLS (NCI) C0908717) =Organic Chemical; Pharmacologic Substance ;
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