[Encoded by human oncogene AKR7A2 Gene, widely expressed 330-amino acid 36.6 kD AFAR polypeptide (Aldo/Keto Reductase 2 Family) is similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase. Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol. AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1. (OMIM, Swiss-Prot, and NCI) ( NCI )]
UMLS (NCI) C0219300 - Amino Acid, Peptide, or Protein
- Enzyme
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