- 1. AF5Q31
- [ALL1 Fused Gene From 5q31, a protein encoded by the AF5q31 gene, is a transcription factor. It is expressed in fetal heart, lung, and brain at relatively high levels and in fetal liver at a low level, but the expression in these tissues is decreased in adults. The AF5q31 protein is homologous to AF4-related proteins, including AF4, LAF4, and FMR2. The AF5q31 and AF4 proteins have 3 homologous regions, including the transactivation domain of AF4. Infantile acute lymphoblastic leukemia (ALL) with rearrangements of the MLL gene is characterized by early pre-B phenotype and poor treatment outcome. The AF5Q31 gene is a fusion partner of the MLL gene involved in the pathogenesis of 11q23-associated ALL. (From LocusLink and OMIM) ( NCI )] (UMLS (NCI) C1332033) ALL1 Fused Gene From 5q31;
ALL1 Fused Gene From Chromosome 5q31;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | |
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