520C9x22 Bispecific Antibody
[A partially humanized bivalent antibody targeting cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) against HER2/neu-overexpressing tumor cells. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody, 520C9, and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody, H22. While HER2/neu is overexpressed in a variety of malignancies, expression of Fc gammaRI is limited primarily to cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells. Therefore, HER2/neu expressing tumor cells bound by MDX-H210 can be selectively recognized by effector cells and triggers antibody-dependent cell-mediated cytotoxicity (ADCC), resulting in tumor cell lysis. ( NCI )]
UMLS (NCI) C0281736- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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