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3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride
[A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. ( NCI )]
UMLS (NCI) C0771055Melphalan Hydrochloride
MELPHALAN HYDROCHLORIDE PREPARATION
MELPHALAN HYDROCHLORIDE PREPARATION
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: 4-[bis(2-chloroethyl)amino]-L-phenylalanine
Relation/CHD: MELPHALAN HYDROCHLORIDE 50 MG
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