- 6801. Amputation of upper limb
- [ ] (UMLS (ICD9CM) C0186399) =Therapeutic or Preventive Procedure
| - 6851. Amyloidoma
- [Amyloidoma - nodular localized form of amyloidosis with predominantly thoracic localization (pulmonary amyloidosis), considered as secondary protein structure diseases in which insoluble protein fibrils accumulate extracellularly. The form of primary amyloid in amyloidoma is characterized by abnormal deposition of light chain proteins composed of monoclonal immunoglobulin. Pulmonary amyloidomas are rare and are often found incidentally as solitary or multiple calcified nodules and masses on chest radiographs in asymptomatic elderly patients. Cavitation is rare, the prognosis is good. ( NCI )] (UMLS (NCI) C0544840) =Neoplastic Process
|
- 6802. Amputation stump complication
- [ ] (UMLS (ICD9CM) C0302473) =Pathologic Function
| - 6852. AMYLOIDOSIS NEC
- [ ] (UMLS (ICD9CM) C0348499) =Disease or Syndrome
|
- 6803. AMPUTATION STUMP REVIS
- [ ] (UMLS (ICD9CM) C0185432) =Therapeutic or Preventive Procedure
| - 6853. amylopectinosis
- [autosomal recessive metabolic disorder due to a deficiency in expression of branching enzyme (alpha-1,4-glucan-6-alpha-glucosyltransferase), resulting in an accumulation of abnormal glycogen with long outer branches; clinical features are muscle hypotonia and cirrhosis; death from liver disease usually occurs before age 2. ( CSP )] (UMLS (CSP) C0017923) =Disease or Syndrome =glycogen storage disease;
|
- 6804. AMPUTATION THROUGH FOOT
- [ ] (UMLS (ICD9CM) C0812427) Transmetatarsal Amputation of Foot;
=Therapeutic or Preventive Procedure ;
| - 6854. amylophosphorylase
- [mobilizes glucose-1-phosphate from glycogen in muscle and other tissues do not use as a general term to cover other phosphorylases (see PHOSPHOTRANSFERASE). ( CSP )] (UMLS (CSP) C0917783) muscle phosphorylase;
phosphorylase;
polyphosphorylase;
=Amino Acid, Peptide, or Protein; Enzyme ;
=hexosyltransferase;
|
- 6805. Amputation through forearm
- [ ] (UMLS (ICD9CM) C0186539) =Therapeutic or Preventive Procedure
| - 6855. amyotonia congenita
- [congenital atonic pseudoparalysis observed especially in infants and characterized by absence of muscular tone only in muscles innervated by the spinal nerves; also known as Oppenheim's disease or syndrome or congenital atonic pseudoparalysis. ( CSP )] (UMLS (CSP) C0002735) =Congenital Abnormality; Disease or Syndrome ;
|
- 6806. AMPUTATION THROUGH HAND
- [ ] (UMLS (ICD9CM) C0187278) =Therapeutic or Preventive Procedure
| - 6856. AN
- [A country in the Caribbean, comprising two island groups in the Caribbean Sea - one includes Curacao and Bonaire north of Venezuela; the other is east of the Virgin Islands. (NCI) ( NCI )] (UMLS (NCI) C0027779) =Geographic Area ;
|
- 6807. Amputation through humerus
- (UMLS (ICD9CM) C0392807) =Therapeutic or Preventive Procedure ;
| - 6857. An age-based population
- (UMLS (HL7) C1548146) =Idea or Concept =Nature of Abnormal Testing;
|
- 6808. AMPUTATION THUMB
- [ ] (UMLS (ICD9CM) C0433638) =Injury or Poisoning
| - 6858. An indicator that Friday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548503) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6809. AMPUTATION THUMB-COMPL
- [ ] (UMLS (ICD9CM) C0160629) =Injury or Poisoning
| - 6859. An indicator that Monday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548504) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6810. AMPUTATION TOE
- [ ] (UMLS (ICD9CM) C0160662) =Injury or Poisoning
| - 6860. An indicator that Saturday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548507) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6811. AMPUTATION TOE-COMPLICAT
- [ ] (UMLS (ICD9CM) C0433625) =Injury or Poisoning
| - 6861. An indicator that Sunday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548508) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6812. Amputee
- (UMLS (HL7) C1546421) =Finding =Ambulatory Status;
| - 6862. An indicator that there is a preferred end time for the appointment request, service or resource.
- (UMLS (HL7) C1548505) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6813. Amputee
- [An entity, facility, or distinct part of a facility providing counseling, fitting, custom design, prescriptive, and training services related to congenital or postoperative absence of all or part of a limb or limbs. ( HL7V3.0 )] (UMLS (HL7) C1552524) =Manufactured Object; Health Care Related Organization =Clinic/Center;
| - 6863. An indicator that there is a preferred start time for the appointment request, service or resource.
- (UMLS (HL7) C1548506) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6814. Amputee clinic
- (UMLS (HL7) C1552766) =Intellectual Product ;
=Outpatient facility;
| - 6864. An indicator that Thursday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548509) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6815. Amsa P-D
- (UMLS (NCI) C0591085) =Organic Chemical; Pharmacologic Substance
| - 6865. An indicator that Tuesday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548510) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6816. AMSA/5-AZA-dCyd
- (UMLS (NCI) C0279490) =Therapeutic or Preventive Procedure
| - 6866. An indicator that Wednesday is or is not preferred for the day on which the appointment will occur.
- (UMLS (HL7) C1548511) =Temporal Concept ;
=Time selection criteria parameter class codes;
|
- 6817. AMSA/ARA-C
- (UMLS (NCI) C0278525) =Therapeutic or Preventive Procedure
| - 6867. An International Standards Organization Object Identifier
- (UMLS (HL7) C1548521) =Intellectual Product =Universal ID type;
|
- 6818. AMSA/ARA-C/BCNU/VP-16
- (UMLS (NCI) C0338282) =Therapeutic or Preventive Procedure ;
| - 6868. An Internet dotted name. Either in ASCII or as integers
- (UMLS (HL7) C1548517) =Intellectual Product =Universal ID type;
|
- 6819. AMSA/ARA-C/DNR
- (UMLS (NCI) C0279007) =Therapeutic or Preventive Procedure ;
| - 6869. An X.400 MHS format identifier
- (UMLS (HL7) C1548526) =Intellectual Product =Universal ID type;
|
- 6820. AMSA/ARA-C/PRED/VCR
- (UMLS (NCI) C0051766) =Therapeutic or Preventive Procedure ;
| - 6870. An X.500 directory name
- (UMLS (HL7) C1548527) =Intellectual Product =Universal ID type;
|
- 6821. AMSA/ARA-C/VP-16
- (UMLS (NCI) C0286421) =Therapeutic or Preventive Procedure ;
| - 6871. AN-9
- (UMLS (NCI) C0103186) =Lipid; Pharmacologic Substance
|
- 6822. AMSA/AZA/VP-16
- (UMLS (NCI) C0083355) =Therapeutic or Preventive Procedure
| - 6872. AN-9/Docetaxel
- (UMLS (NCI) C1328148) =Therapeutic or Preventive Procedure ;
|
- 6823. AMSA/CTX/HU
- (UMLS (NCI) C0280058) =Therapeutic or Preventive Procedure
| - 6873. ANA, positive antinuclear antibodies
- [Antibodies directed against nuclear antigens; almost invariably found in systemic lupus erythematosus and are frequently found in rheumatoid arthritis, scleroderma, Sjogren's Syndrome and mixed connective tissue disease. ( NCI )] (UMLS (NCI) C0151480) =Finding ;
|
- 6824. AMSA/CTX/VP-16
- (UMLS (NCI) C0278621) =Therapeutic or Preventive Procedure
| - 6874. Anabaena
- [A genus of CYANOBACTERIA consisting of trichomes that are untapered with conspicuous constrictions at cross-walls. A firm individual sheath is absent, but a soft covering is often present. Many species are known worldwide as major components of freshwater PLANKTON and also of many saline lakes. The species ANABAENA FLOS-AQUAE is responsible for acute poisonings of various animals. ( MSH )] (UMLS (CSP) C0085540) =Bacterium ;
|
- 6825. AMSA/VP-16
- (UMLS (NCI) C0278922) =Therapeutic or Preventive Procedure
| - 6875. anabolic steroid
- [Synthetic derivatives of the male hormone, androgen, that promote tissue growth by increasing the metabolic processes involved with protein synthesis and are used to promote weight gain in wasting diseases. They are used by bodybuilders and athletes to increase muscle mass, strength, and stamina. ( NCI )] (UMLS (CSP) C0002744) =Steroid; Pharmacologic Substance ;
|
- 6826. AMSH
- [Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. This protein binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink) ( NCI )] (UMLS (NCI) C1101604) AMSH Protein;
Associated Molecule with the SH3 Domain of STAM =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 6876. anabolism
- [general term for synthesis of chemical compounds by living organisms. ( CSP )] (UMLS (CSP) C0220781) =Biologic Function =Intermediary Metabolism;
=Amino Acid Biosynthesis;
blood lipoprotein biosynthesis;
carbohydrate biosynthesis;
hormone biosynthesis;
membrane biogenesis;
neurotransmitter biosynthesis;
nucleic acid biosynthesis;
porphyrin biosynthesis;
protein biosynthesis;
steroid biosynthesis;
vitamin biosynthesis;
molecular assembly;
lipid biosynthesis;
|
- 6827. Amsidyl
- (UMLS (NCI) C0919345) =Organic Chemical; Pharmacologic Substance ;
| - 6877. Anacystisnidulans
- [ ] (UMLS (CSP) C0597952) =Bacterium ;
|
- 6828. AMV
- (UMLS (NCI) C0280591) =Therapeutic or Preventive Procedure
| - 6878. anaerobe
- [see RTs for specific organisms. ( CSP )] (UMLS (CSP) C0004613) =Bacterium ;
|
- 6829. AMVP
- (UMLS (NCI) C0279219) =Therapeutic or Preventive Procedure
| - 6879. Anaerobic Culture
- [Culture, Anaerobic ( HL7V3.0 )] (UMLS (HL7) C1273935) =Laboratory Procedure =ObservationMethod;
|
- 6830. AMYB
- [A DNA-binding, transcriptional activator with a possible role in proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. A-Myb specifically recognizes the DNA sequence 5'-YAAC(G/T)G-3' and belongs to the Myb family. (from SWISS-PROT P10243, OMIM 159405, and NCI) ( NCI )] (UMLS (NCI) C0258050) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 6880. anaerobic glycolysis
- [ ] (UMLS (CSP) C0872016) =Molecular Function ;
|
- 6831. amygdala
- [almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; part of the limbic system. ( CSP )] (UMLS (CSP) C0002708) =Body Part, Organ, or Organ Component
| - 6881. ANAEROBIC MENINGITIS
- [ ] (UMLS (ICD9CM) C0375197) =Disease or Syndrome
|
- 6832. Amygdalin
- [A cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. Amygdalin is converted by plant emulsin (a combination of a glucosidase and a nitrilase) or hydrochloric acid into benzaldehyde, D-glucose, and hydrocyanic acid. (NCI04) ( NCI )] (UMLS (NCI) C0002707) =Carbohydrate; Pharmacologic Substance ;
| - 6882. ANAEROBIC SEPTICEMIA
- [ ] (UMLS (ICD9CM) C0152967) =Disease or Syndrome
|
- 6833. amyl nitrite
- [A vasodilator that is administered by inhalation. It is also used recreationally due to its supposed ability to induce euphoria and act as an aphrodisiac. ( MSH )] (UMLS (CSP) C0002711) =Organic Chemical; Pharmacologic Substance ;
| - 6883. anaerobiosis
- [metabolic processes occurring in the absence of molecular oxygen. ( CSP )] (UMLS (CSP) C0002750) =Organism Function
|
- 6834. amylase
- [(AM-il-aze) An enzyme that helps the body digest starches. ( NCI )] (UMLS (CSP) C0002712) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
| - 6884. Anafranil
- [ ] (UMLS (CSP) C0002752) =Organic Chemical; Pharmacologic Substance ;
|
- 6835. Amylase
- [A measurement of the pancreatic enzyme amylase in a biological specimen. ( NCI )] (UMLS (NCI) C0201883) =Laboratory Procedure
| - 6885. Anagrelide
- [A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04) ( NCI )] (UMLS (NCI) C0051809) =Organic Chemical; Pharmacologic Substance ;
=quinazoline;
[BL400] BLOOD FORMATION PRODUCTS =Anagrelide Hydrochloride |
- 6836. amylase inhibitor
- [ ] (UMLS (CSP) C0597832) =Pharmacologic Substance =enzyme inhibitor;
| - 6886. Anagrelide Hydrochloride
- [The hydrochloride salt of a synthetic quinazoline derivative, Anagrelide Hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04) ( NCI )] (UMLS (NCI) C0771907) ANAGRELIDE HYDROCHLORIDE PREPARATION;
=Organic Chemical; Pharmacologic Substance =Anagrelide;
=ANAGRELIDE HYDROCHLORIDE 0.5 MG;
ANAGRELIDE HYDROCHLORIDE 1 MG;
|
- 6837. amylin
- [37-amino acid polypeptide occurring packaged with insulin in the beta cell secretory granules in normal pancreatic islets; also, a major component of islet amyloid in patients with noninsulin dependent diabetes mellitus. ( CSP )] (UMLS (CSP) C0063684) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =Interacinar Cell Pancreatic Polypeptide;
| - 6887. Anakinra
- [A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04) ( NCI )] (UMLS (NCI) C0245109) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=[MS109] ANTIRHEUMATICS, OTHER;
Unclassified Ingredients =ANAKINRA 100 MG |
- 6838. amylo 1,4:1,6 transglucosidase deficiency
- [ ] (UMLS (CSP) C0677581) =Disease or Syndrome
| - 6888. anal
- [The lower opening of the digestive tract, lying in the cleft between the buttocks, through which fecal matter is extruded. ( NCI )] (UMLS (NCI) C0003461) =Body Part, Organ, or Organ Component
|
- 6839. amylo 1,6 glucosidase
- [ ] (UMLS (CSP) C0051775) =Amino Acid, Peptide, or Protein; Enzyme
| - 6889. ANAL & RECTAL POLYP
- (UMLS (ICD9CM) C0002753) =Pathologic Function
|
- 6840. amylo 1,6 glucosidase deficiency
- [autosomal recessive metabolic disorder due to deficient expression of amylo-1,6-glucosidase; clinical course is similar to that of glycogen storage disease type I, but milder; massive hepatomegaly, which is present in young children, diminishes and occasionally disappears with age; levels of glycogen with short outer branches are elevated in muscle, liver, and erythrocytes. ( CSP )] (UMLS (CSP) C0017922) =Disease or Syndrome =glycogen storage disease;
| - 6890. ANAL ANASTOMOSIS
- [ ] (UMLS (ICD9CM) C0176809) =Therapeutic or Preventive Procedure
|
- 6841. Amyloid Beta (A4) Precursor Protein (Protease Nexin-II, Alzheimer Disease) Gene
- [This gene is involved in transcriptional activation and mutations in the gene are correlated with Alzheimer disease. ( NCI )] (UMLS (NCI) C1364818) APP;
APP Gene;
=Gene or Genome | - 6891. Anal Basaloid Carcinoma
- [An anal squamous cell carcinoma characterized by the presence of malignant cells with hyperchromatic nuclei and peripheral nuclear palisading. ( NCI )] (UMLS (NCI) C0280470) =Neoplastic Process ;
|
- 6842. Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2
- [Encoded by human APPBP2 Gene, ubiquitous 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats. In the Golgi apparatus, APPBP2 is associated with transport or processing of amyloid precursor protein (APP). Cell surface sorting of the signal-transducing APP depends on a cytoplasmic tyrosine-based basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds. Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport. Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting. APPBP2 is abundantly expressed in breast cancer. (from OMIM, and NCI) ( NCI )] (UMLS (NCI) C1332256) Amyloid Beta Precursor Protein-Binding Protein 2;
APPBP2;
PAT1 Protein;
Protein Interacting with APP Tail 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 6892. ANAL BIOPSY
- [Removal of tissue from the anus for microscopic examination. ( NCI )] (UMLS (ICD9CM) C0193114) =Diagnostic Procedure
|
- 6843. Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Gene
- [This gene plays a role in the regulation of protein transport and microtubule dynamics. The gene has also been implicated in the pathogenesis of Alzheimer's disease. ( NCI )] (UMLS (NCI) C1332104) APPBP2;
APPBP2 Gene =Gene or Genome ;
| - 6893. Anal Buschke-Lowenstein Tumor
- [A large, well differentiated squamous cell carcinoma with a cauliflower-like appearance, characterized by the presence of an exophytic and endophytic growth pattern. Morphologically, there is papillomatosis and acanthosis present, however cytologically the neoplastic squamous cells have a benign appearance. Dysplastic changes are minimal. It does not respond to conservative treatment and it is regarded by many authors as an intermediate lesion between condyloma acuminatum and squamous cell carcinoma. ( NCI )] (UMLS (NCI) C1332278) Anal Giant (Malignant) Condyloma;
Anal Verrucous Carcinoma;
=Neoplastic Process |
- 6844. Amyloid Beta-Peptide Pathway
- [Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a primary component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, reduction of beta-amyloid formation may prevent the development and progression of disease symptoms. Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space. APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE. Beta-secretase activity, recently identified as BACE, cleaves in the N-terminus of the beta-amyloid fragment. Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage. The gamma-secretase activity requires the transmembrane protein Presenilin-1 that is itself cleaved into an N-terminal and C-terminal fragment that both are required for gamma-secretase activity. Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease. Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease. Other mechanisms may include altering degradation of beta-amyloid, and the use of vaccines against beta-amyloid to remove aggregates. (BioCarta) ( NCI )] (UMLS (NCI) C1510880) Generation of amyloid b-peptide by PS1;
=Molecular Function ;
| - 6894. Anal Canal
- [Organ with organ cavity which is continuous proximally with the rectum and distally terminates with the anus. Examples: There is only one anal canal. ( UWDA )] (UMLS (NCI) C0227411) =Body Part, Organ, or Organ Component
|
- 6845. amyloid disease
- [any disease manifested by the pathogenic accumulation of amyloid in organs and tissues. ( CSP )] (UMLS (CSP) C0002726) =Disease or Syndrome
| - 6895. Anal Canal and Perianal Gland Cancer
- [A squamous cell carcinoma or less frequently an adenocarcinoma, often associated with human papilloma virus (HPV) infection. Homosexual men are at particular risk. The most important prognostic factors are tumor stage and nodal status. — 2003 ( NCI )] (UMLS (NCI) C0563211) =Neoplastic Process ;
|
- 6846. Amyloid Fibril Interaction
- [Amyloid Fibril Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with insoluble forms of a secretase-processed metal ion-binding type I cell surface glycoprotein (APP Family) required for endocytosis and BaSS sorting; important in developing synapses, for cell mobility, adhesion, and axonogenesis; and Notch signaling inhibitor, copper homeostasis regulator, transcription activator, and apoptosis enhancer. ( NCI )] (UMLS (NCI) C1510881) =Molecular Function ;
| - 6896. Anal Canal Carcinoma in situ
- [Stage 0 anal cancer corresponds to the following TNM grouping: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th Ed.) - 2003 ( NCI )] (UMLS (NCI) C0154064) =Neoplastic Process
|
- 6847. amyloid precursor protein
- [A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging. ( MSH )] (UMLS (CSP) C0085151) =Amino Acid, Peptide, or Protein ;
| - 6897. Anal Canal Cloacogenic Carcinoma
- [An anal carcinoma arising from the transitional zone of the anal canal. ( NCI )] (UMLS (NCI) C0334273) =Neoplastic Process
|
- 6848. Amyloid Precursor Protein Secretase
- [Cathepsin B, encoded by the CTSB Gene, encodes a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinoma. Gastric carcinoma cells that oversecrete cathepsins B have a high invasive and metastatic potential. At least five transcript variants encoding the same protein have been found for this gene. (From LocusLink, PMID 10931446 and NCI) ( NCI )] (UMLS (NCI) C0699919) =Amino Acid, Peptide, or Protein; Enzyme =caspase;
| - 6898. Anal Canal Intraepithelial Neoplasia
- [A precancerous neoplastic intraepithelial process involving the squamous and transitional zones of the anal canal. When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules. Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures. It may be classified as low or high grade. ( NCI )] (UMLS (NCI) C1332260) Anal Canal Squamous Dysplasia;
Squamous Dysplasia in the Anal Canal =Neoplastic Process |
- 6849. amyloid protein
- [extracellular glycoprotein that accumulates in certain pathological conditions, e.g., the paired helical filaments of neuritic plaques in Alzheimer's disease and Down's syndrome; use this term for both the precursor and beta form. ( CSP )] (UMLS (CSP) C1456454) =Amino Acid, Peptide, or Protein; Biologically Active Substance =glycoprotein;
fibrous protein | - 6899. Anal Canal Paget's Disease
- [Paget disease involving the squamous epithelium of the anal canal. ( NCI )] (UMLS (NCI) C1332261) Paget Disease of the Anal Canal;
Paget's Disease of Anal Canal;
Paget's Disease of the Anal Canal;
=Neoplastic Process |
- 6850. Amyloid Resorption Induction
- [Amyloid Resorption Induction involves initiation of activities of involved in the breakdown and assimilation of amyloid deposits. ( NCI )] (UMLS (NCI) C1510882) =Molecular Function ;
| - 6900. Anal Canal Squamous Cell Carcinoma
- [A squamous cell carcinoma arising from the mucosa of the anal canal. ( NCI )] (UMLS (NCI) C1332262) =Neoplastic Process
|
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