[Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. This protein binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink) ( NCI )]
UMLS (NCI) C1101604AMSH Protein
Associated Molecule with the SH3 Domain of STAM
- Amino Acid, Peptide, or Protein
- Biologically Active Substance