- 401. 1,1'-[(methylethanediylidene)dinitrilo)diguanidine
- [A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0026251) =Organic Chemical; Pharmacologic Substance ;
=hydrazone;
| - 451. 1,2-Dihydroxypropane
- [A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. ( MSH )] (UMLS (NCI) C0072225) =Organic Chemical; Biomedical or Dental Material =propanediol;
PROPYLENE =PROPYLENE GLYCOL STEARATE;
PROPYLENE GLYCOL DIACETATE;
CONTACT LENS CLEANING SOLN;
COAL TAR DISTILLATE;
MASSENGILL DISPOSABLE DOUCHE;
TING PWDR,TOP;
fluticasone 0.5 MG/ML Topical Cream;
KERI LOTION;
fluticasone 0.00005 MG/MG Topical Ointment;
CAFFEINE 200 MG Oral (systemic) tablet;
Urea 0.1 MG/MG Topical Ointment;
UREA 25% LOTION;
CETAPHIL CREAM;
CETAPHIL LOTION; More… |
- 402. 1,1,1,2,2,2-Hexachloroethane
- [A crystalline, colorless, toxic, solid chlorinated hydrocarbon with a camphor-like odor and emits toxic and irritating fumes when heated to decomposition. Hexachloroethane was used as an anthelmintic to treat fascioliasis in cattle and sheep, in refining aluminum alloys, in smoke bombs and pyrotechnic and as a degassing agent and polymer additive. Exposure to this substance irritates the skin and mucous membranes, causes liver damage and acts as a central nervous system depressant. Hexachloroethane is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0062606) =Organic Chemical; Pharmacologic Substance ;
| - 452. 1,2-Dimethylhydrazine
- [A compound used experimentally to induce tumors in animal models of carcinogenesis. In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis through deregulation of the cell cycle. This agent primarily induces gastrointestinal and vascular tumors. 1,2-Dimethylhydrazine may be found in small amounts in the environment due to its use in industry and agriculture. (NCI04) ( NCI )] (UMLS (NCI) C0043833) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 403. 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
- [A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. ( NCI )] (UMLS (NCI) C0074414) =Organic Chemical; Pharmacologic Substance ;
=Methyl Ethers;
[CN201] ANESTHETICS INHALATION =SEVOFLURANE LIQUID (ML) | - 453. 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative
- [A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. ( NCI )] (UMLS (NCI) C0054015) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[CV900] CARDIOVASCULAR AGENTS, OTHER;
Unclassified Ingredients =NESIRITIDE RECOMBINANT |
- 404. 1,1,1-Trifluoro-2-bromo-2-chloroethane
- [potent inhalation anesthetic widely used for induction and maintenance of general anesthesia. ( CSP )] (UMLS (NCI) C0018549) =Organic Chemical; Pharmacologic Substance =[CN200] ANESTHETICS;
Halogenated Hydrocarbon;
[CN201] ANESTHETICS INHALATION;
haloalkane =HALOTHANE 100 % | - 454. 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane Cyclic Peptide Deriv
- [potent, long-acting synthetic somatostatin octapeptide analog. ( CSP )] (UMLS (NCI) C0028833) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[GA400] ANTIDIARRHEAL AGENTS;
cyclic peptide;
AY 24910;
peptide hormone analog =D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide Acetate |
- 405. 1,1,2,2-Tetrachloroethylene
- [A colorless, volatile, nonflammable, liquid, chlorinated hydrocarbon with an ether-like odor that may emit toxic fumes of phosgene when exposed to sunlight or flames. Tetrachloroethylene is mainly used as a cleaning solvent in dry cleaning and textile processing and in the manufacture of fluorocarbons. Exposure to this substance irritates the upper respiratory tract and eyes and causes neurological effects as well as kidney and liver damage. Tetrachloroethylene is reasonably anticipated to be a human carcinogen and may be linked to an increased risk of developing skin, colon, lung, esophageal, and urogenital tract cancer as well as lymphosarcoma and leukemia. (NCI05) ( NCI )] (UMLS (NCI) C0039637) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 455. 1,2-Dithioglycerol
- [A metal chelating agent that is used as an antidote in arsenic, gold, lead, mercury and other heavy metal poisoning. Metals form ligands in the body with the sulfhydryl groups of the pyruvate-oxidase enzyme system. This leads to an inhibition of the normal functioning of these enzymes that are dependent on free sulfhydryl groups for their activity. Dimercaprol reverses the enzyme inhibition by chelating the metal and regenerates free sulfhydryl groups, thereby preventing and reversing the metals toxic effects. ( NCI )] (UMLS (NCI) C0012383) =Organic Chemical; Pharmacologic Substance ;
=mercaptan;
[AD300] HEAVY METAL ANTAGONISTS =DIMERCAPROL 100 MG/ML |
- 406. 1,1,2,2-Tetrafluoroethylene
- [A synthetic, colorless, flammable gas that is insoluble in water. Tetrafluoroethylene is used primarily in the synthesis of polytetrafluoroethylene resins. It is also used as a monomer in the synthesis of copolymers and as a propellant for food product aerosols. When heated to decomposition, tetrafluoroethylene emits highly toxic fluorocarbon fumes. The primary route of human exposure to this compound is inhalation. Acute inhalation exposure to tetrafluoroethylene may result in irritation of the respiratory tract and buildup of fluid in the lungs (pulmonary edema). Contact with this gas can cause eye irritation. This chemical is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0076258) =Organic Chemical
| - 456. 1,2-Dithiole-3-thione
- (UMLS (NCI) C0043854) =Organic Chemical; Pharmacologic Substance ;
|
- 407. 1,1-Dichloro-2-chloroethylene
- [toxic liquid widely used as an industrial solvent, formerly used as an inhalation anesthetic. ( CSP )] (UMLS (NCI) C0040905) =Organic Chemical; Pharmacologic Substance =[CN200] ANESTHETICS;
haloalkene | - 457. 1,2-Epoxyethane
- [Colorless, odorless, flammable, toxic gaseous cyclic ether with a sweet ether-like smell. Ethylene oxide is used especially in the synthesis of ethylene glycol and as a sterilizing agent for medical supplies and foods, as a fumigant and as an insecticide. Exposure to this substance is highly irritating to the eyes, skin and respiratory tract, induces nausea and vomiting and causes central nervous system depression. Ethylene oxide is mutagenic in humans and chronic exposure is associated with an increased risk of leukemia, stomach cancer, pancreatic cancer and non-Hodgkin's lymphoma. (NCI05) ( NCI )] (UMLS (NCI) C0015087) =Organic Chemical; Hazardous or Poisonous Substance ;
=epoxide;
|
- 408. 1,1-Dimethylbiguanide
- [A biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. ( NCI )] (UMLS (NCI) C0025598) =Organic Chemical; Pharmacologic Substance =Biguanides;
antihyperglycemic;
[HS502] HYPOGLYCEMIC AGENTS, ORAL;
=1,1-Dimethylbiguanide Hydrochloride | - 458. 1,2-Epoxyethylbenzene
- [A synthetic, colorless liquid that is very soluble in water. Styrene oxide is used as a chemical intermediate in the production of styrene glycol and its derivatives, cosmetics, surface coatings and other chemicals (agricultural and biological). It is also used as a reactive diluent for epoxy resins and in cross-linked polyesters and polyurethanes. Humans in the general population may be exposed to styrene oxide by contact with contaminated air or water. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0075351) =Organic Chemical
|
- 409. 1,1-Dimethylbiguanide Hydrochloride
- [The hydrochloride salt form of metformin, a biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. ( NCI )] (UMLS (NCI) C0770893) Metformin HCl;
Metformin Hydrochloride;
METFORMIN HYDROCHLORIDE PREPARATION;
N,N-Dimethylimidodicarbonimidic Diamide Monohydrochloride =Organic Chemical; Pharmacologic Substance =1,1-Dimethylbiguanide;
=METFORMIN HYDROCHLORIDE 1000 MG;
METFORMIN HYDROCHLORIDE 500 MG;
METFORMIN HYDROCHLORIDE 850 MG;
METFORMIN HYDROCHLORIDE 250 MG | - 459. 1,2-Epoxypropane
- [A synthetic, highly-flammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. Propylene oxide is used primarily as a chemical intermediate in the production of polyethers and propylene glycol. It is also used as a pesticide and a fumigant for the sterilization of packaged foods and plastic medical instruments. Acute inhalation exposure to vapors of this compound can result in respiratory tract irritation, coughing, difficulty in breathing (dyspnea) and buildup of fluid in the lungs (pulmonary edema) that can possibly lead to pneumonia. Inhale high concentrations of the vapors for short time periods may cause headache, motor weakness, incoordination, ataxia and coma. Contact with propylene oxide can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0072229) =Organic Chemical
|
- 410. 1,1-Dimethylhydrazine
- [A clear, colorless, flammable, hygroscopic liquid with a fishy smell that emits toxic fumes of nitrogen oxides when heated to decomposition, and turns yellow upon contact with air. 1,1-Dimethylhydrazine is mainly used as a high-energy fuel in jets and rockets, but is also used in chemical synthesis, in photography and to control the growth of vegetation. This substance is also found in tobacco products. Exposure to 1,1-dimethylhydrazine results in irritation of skin, eyes and mucous membranes, and can affect liver and central nervous system. 1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0058187) =Organic Chemical
| - 460. 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, Monohydrochloride
- [The hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1 receptors, thereby limiting histamine's effects, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic activity. ( NCI )] (UMLS (NCI) C0304297) =Organic Chemical; Pharmacologic Substance ;
=TRIPELENNAMINE;
=TRIPELENNAMINE HYDROCHLORIDE 100 MG;
TRIPELENNAMINE HYDROCHLORIDE 2 %;
TRIPELENNAMINE HYDROCHLORIDE 0.5 % |
- 411. 1,1-Hydrazodibenzene
- [A colorless, crystalline compound that emits toxic fumes of nitrogen oxides when heated to decomposition. Hydrazobenzene has been used primarily in the dye manufacturing industry as the precursor of the dye intermediate benzidine and is also used as an intermediate in the manufacture of pharmaceuticals. Exposure to this substance irritates the skin, nose, throat and lungs and can eventually lead to liver, kidney and brain damage. Hydrazobenzene is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0063069) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 461. 1,2-Oxathiolane 2,2-Dioxide
- [A synthetic, colorless liquid or white crystalline solid that is readily soluble in water and many organic solvents such as ketones, esters and aromatic hydrocarbons. 1,3-propanesultone is used as a chemical intermediate in the production of detergents, dyes, lathering agents, bacteriostats, fungicides, insecticides, cation-exchange resins, corrosion inhibitors and vulcanization accelerators. When heated to decomposition, it emits toxic fumes of sulfur oxides. Humans are potentially exposed to residues of 1,3-propane sultone when using products manufactured from this compound. The primary routes of potential human exposure to 1,3-propane sultone are ingestion and inhalation. Contact with this chemical can cause mild irritation of the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043970) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
|
- 412. 1,10-(1,2-Phenylene)pyrene
- [A yellowish, aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Indene[1,2,3-cd]pyrene is primarily found in certain foods, gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, soot and petroleum asphalt. This substance is used only for research purposes. Indene[1,2,3-cd]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0063458) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 462. 1,2-Propyleneimine
- [A synthetic, flammable, volatile, colorless oily liquid that is soluble in water, ethanol and most organic solvents. Propylenimine is used in the United States exclusively as an intermediate, and its derivatives are used in the paper, textile, rubber and pharmaceutical industries. Due to its volatility, potential exposure could occur during production, packaging, or use of substances made with this liquid. The primary routes of potential human exposure to propylenimine are inhalation, ingestion and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0072231) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 413. 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
- [A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C0936065) 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-;
Becatecarin;
DEAE-Rebeccamycin;
Rebeccamycin analog;
Rebeccamycin Analogue;
=Organic Chemical; Antibiotic ;
| - 463. 1,25 (OH) vitamin D
- [ ] (UMLS (CSP) C0370232) =Organic Chemical; Vitamin
|
- 414. 1,12 (OH) D3
- [ ] (UMLS (CSP) C0750730) 1,12(OH)D3 =Inorganic Chemical ;
| - 464. 1,25-Dihydroxy-16-ene-23-yne-Vitamin D3
- (UMLS (NCI) C0526577) =Steroid; Pharmacologic Substance
|
- 415. 1,14-bis(ethylamino)-5,10-diazatetradecane
- [A polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity are developed. ( NCI )] (UMLS (NCI) C0067118) =Organic Chemical; Pharmacologic Substance ;
| - 465. 1,25-Dihydroxyvitamin D3 Receptor
- [use for receptors of any of the D vitamins. ( CSP )] (UMLS (NCI) C0108082) =Amino Acid, Peptide, or Protein; Receptor =vitamin receptor;
|
- 416. 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachloro-octahydro-1,3,4-metheno-1H-cyclbuta[cd]pentalene
- [A white, stable, odorless, synthetic, crystalline solid chlorinated hydrocarbon. Mirex was used as an insecticide against ants and as a fire-retardant for plastics, paint, rubber, paper and electrical appliances, but it is no longer produced or used in the US. Exposure to Mirex irritates the skin and eyes and causes a headache as well as dizziness, nausea and vomiting and affects the central nervous system, lungs, liver and kidneys. Mirex is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0026209) =Organic Chemical; Hazardous or Poisonous Substance
| - 466. 1,2:15,16-Diepoxy-4,7,10, 13-tetraoxahexadecane
- [Alkylating antineoplastic agent used especially in bladder neoplasms. It is toxic to hair follicles, gastro-intestinal tract, and vasculature. ( MSH )] (UMLS (NCI) C0015039) =Organic Chemical; Pharmacologic Substance ;
|
- 417. 1,2 diazole
- [5-membered aromatic ring structure with 2 adjacent nitrogen heteroatoms. ( CSP )] (UMLS (CSP) C0072662) =Organic Chemical ;
=azole;
=antipyrine | - 467. 1,3 diazine
- [ ] (UMLS (CSP) C0034284) =Organic Chemical ;
|
- 418. 1,2 dihydroxybenzene
- [A chemical originally isolated from a type of mimosa tree. Catechol is used as an astringent, an antiseptic, and in photography, electroplating, and making other chemicals. It can also be man-made. ( NCI )] (UMLS (NCI) C0054858) =Organic Chemical; Pharmacologic Substance
| - 468. 1,3, 4-Thiadiazol-2-amine (9CI)
- [A synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase, thereby disrupting the regulation of cell proliferation and differentiation in a number of cells. This agent is also a selective human adenosine A3 receptor antagonist. (NCI04) ( NCI )] (UMLS (NCI) C0092419) =Organic Chemical; Pharmacologic Substance
|
- 419. 1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic Acid Delta-Lactone
- [A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. (NCI04) ( NCI )] (UMLS (NCI) C0039600) =Steroid; Pharmacologic Substance; Hormone =Androstadienes;
Homosteroids;
[AN500] ANTINEOPLASTIC HORMONES;
=TESTOLACTONE 50 MG | - 469. 1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI)
- [5 azacytosine arabinoside; USP lists as an antineoplastic agent. ( CSP )] (UMLS (NCI) C0060103) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
.beta.-Cytosine arabinoside;
nucleoside analog;
|
- 420. 1,2,3,4-Dibenzopyrene
- [A yellowish-reddish, carcinogenic aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in coal gasification products, cigarette smoke and fossil fuels. This substance is used only for research purposes to induce tumorigenesis. Dibenzo[a,e]pyrene is a mutagen and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0057769) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 470. 1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic Acid
- [A pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2. ( NCI )] (UMLS (NCI) C0059865) =Organic Chemical; Pharmacologic Substance =Indoleacetic Acids;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =ETODOLAC 200 MG;
ETODOLAC 300 MG;
ETODOLAC 400 MG;
ETODOLAC 500 MG;
ETODOLAC 600 MG;
|
- 421. 1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-[(1E)-1-methyl-2-phenylethenyl]naphthalene
- (UMLS (NCI) C0076076) =Organic Chemical ;
| - 471. 1,3,5(10)-Estratrien-2,3-diol-17-one
- (UMLS (NCI) C0046200) =Steroid; Pharmacologic Substance ;
|
- 422. 1,2,3,4-Tetrahydro-1-(3,4,5-trimethoxybenzyl)-6,7-isoquinolinediol
- [An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy. ( MSH )] (UMLS (NCI) C0040846) =Organic Chemical; Pharmacologic Substance
| - 472. 1,3,5(10)-Estratrien-3-ol-17-one
- [aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen; converted from androstenedione directly, or from testosterone via estradiol; in humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. ( CSP )] (UMLS (NCI) C0014942) =Steroid; Pharmacologic Substance; Hormone =17-Ketosteroids;
Estrenes;
[HS300] ESTROGENS;
=Estrone Hydrogen Sulfate compound with Piperazine(1:1);
Estrone Sodium Sulfate;
ESTRONE 1.5 MG;
ESTRONE 1.5 MG/ML;
ESTRONE 2 MG/ML;
ESTRONE 2.5 MG;
ESTRONE 5 MG/ML;
ESTRONE 2 MG |
- 423. 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate
- [The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not been fully elucidated, tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine, and prolonging synaptic actions as well as increased release of acetylcholine. In addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus and blood, thereby producing central and peripheral anti-inflammatory effects that may play a role in Alzheimer's disease. ( NCI )] (UMLS (NCI) C0771182) Hydroaminacrine;
TACRINE HYDROCHLORIDE;
TACRINE HYDROCHLORIDE PREPARATION;
=Organic Chemical; Pharmacologic Substance =tacrine;
=TACRINE HYDROCHLORIDE 20 MG;
TACRINE HYDROCHLORIDE 40 MG;
TACRINE HYDROCHLORIDE 10 MG;
TACRINE HYDROCHLORIDE 30 MG | - 473. 1,3,5-triazin-2(1H)-one, 4-amino-3, 6-dihydro-1-beta-D-ribofuranosyl monohydrochloride
- (UMLS (NCI) C0952659) 5,6-dihydro-5-azacytidine HCl;
5,6-Dihydro-5-azacytidine hydrochloride =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance |
- 424. 1,2,3-Propanetricarboxylic Acid, 2-hydroxy-, Gallium-(sup 67)Ga(1:1) Salt
- [A radioactive salt of gallium used as a radiopharmaceutical. The exact mechanism of action is unknown, but gallium citrate Ga-67 has been found to concentrate in certain viable primary and metastatic tumors as well as focal sites of inflammation. Adequate blood supply is essential for delivery of gallium citrate Ga-67 to the lesion. Gallium citrate Ga-67 is used as a diagnostic tool in neoplastic disease and inflammatory lesions. (NCI05) ( NCI )] (UMLS (NCI) C0893383) Gallium 67 citrate;
Gallium Citrate Ga-67;
GALLIUM CITRATE, GA-67;
GALLIUM CITRATE,GA-67;
GALLIUM CITRATE,GA-67 PREPARATION =Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical =gallium citrate;
[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS =GALLIUM CITRATE,GA-67 2 MIL;
| - 474. 1,3,5-Triazine-2,4,6-triamine, N,N,N',N', N''-pentamethyl-, monohydrochloride (9CI)
- (UMLS (NCI) C0890530) Melamine, N2,N2,N4,N4,N6-pentamethyl-, monohydrochloride;
Pentamethylmelamine monoHCl;
Pentamethylmelamine monohydrochloride =Organic Chemical; Pharmacologic Substance |
- 425. 1,2,3-Propanetriol
- [1,2,3-trihydroxypropane, a key intermediate in glucose metabolism; also serves as the bridge between hydrophobic "tails" and hydrophilic "heads" of many membrane lipids; reagent is used as a water-soluble solvent and lubricant. ( CSP )] (UMLS (NCI) C0017861) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =[DE350] EMOLLIENTS;
sugar alcohol;
triose;
[OP106] OSMOTIC AGENTS, SYSTEMIC OPHTHALMIC;
[RS300] LAXATIVES, RECTAL;
[OP500] EYE WASHES/LUBRICANTS;
[OP900] OPHTHALMICS, OTHER;
=glyceryl trinitrate;
GLYCEROL,IODINATED;
thioglycerol;
GREEN SOAP;
AQUANIL LOTION;
MOISTUREL CREAM,TOP;
MOISTUREL More… | - 475. 1,3,7-trimethylxanthine
- [1,3,7-trimethylxanthine, a central nervous system stimulant; action may be mediated by adenosine receptors. ( CSP )] (UMLS (NCI) C0006644) =Organic Chemical; Pharmacologic Substance ;
=alkaloid;
[CN800] CNS STIMULANTS;
Xanthine Alkaloids;
xanthine;
methylpurine;
[CN809] CNS STIMULANTS, OTHER =Caffeina Citrata;
CAFFEINE 100 MG;
CAFFEINE 125 MG/ML;
CAFFEINE 30 MG;
CAFFEINE 32 MG;
CAFFEINE 40 MG;
CAFFEINE 65 MG;
CAFFEINE 200 MG;
CAFFEINE 20 MG/ML;
CAFFEINE 16 MG;
CAFFEINE 60 MG;
CAFFEINE 33 MG;
CAFFEINE 32.4 MG;
CAFFEINE 36 MG;
CAFFEINE 25 MG/5ML;
CAFFEINE 16.25 MG |
- 426. 1,2,3-Propanetriyl Butanoate
- [A triglyceride drug that may inhibit cell growth and induce cell differentiation. Differentiating agents may be effective in changing cancer cells back into normal cells. ( NCI )] (UMLS (NCI) C0077025) =Lipid; Pharmacologic Substance ;
| - 476. 1,3,8-Trihydroxy-6-methylanthraquinone
- [Purgative anthraquinone found in several plants, especially Rhamnus frangula. It was formerly used as a laxative, but is now used mainly as tool in toxicity studies. ( MSH )] (UMLS (NCI) C0013982) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =Cascara;
=alloin;
|
- 427. 1,2,3-Trichloropropane
- [A synthetic, colorless to light yellow liquid that is soluble in polar organic solvents and only slightly soluble in water. 1,2,3-Trichloropropane is used as both a chemical intermediate and cross-linking agent in the production of polymers. 1,2,3-Trichloropropane is flammable and, when heated to decomposition, emits toxic fumes of hydrogen chloride. Exposure of humans to 1,2,3-trichloropropane vapor causes irritation of the eyes and throat. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043760) =Organic Chemical
| - 477. 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate(2:1)(Salt)
- [The sulfate salt form of metaproterenol, a short-acting and selective sympathomimetic beta-receptor agonist with bronchodilator activity. Metaproterenol sulfate binds beta-2 adrenergic receptors in bronchial smooth muscle and stimulates intracellular adenyl cyclase, thereby increasing the production of cyclic adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, improve mucocliary clearance and reduce inflammatory cell mediator release, especially from mast cells. ( NCI )] (UMLS (NCI) C0025573) =Organic Chemical; Pharmacologic Substance =METAPROTERENOL;
=METAPROTERENOL SULFATE 0.4 %;
METAPROTERENOL SULFATE 0.6 %;
METAPROTERENOL SULFATE 0.65 MG/ACTUAT;
METAPROTERENOL SULFATE 10 MG;
METAPROTERENOL SULFATE 10 MG/5ML;
METAPROTERENOL SULFATE 20 MG;
METAPROTERENOL SULFATE 5 %;
|
- 428. 1,2,4,5-Dibenzopyrene
- [A yellowish-reddish, aromatic hydrocarbon consisting of six fused rings and produced by incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in gasoline exhaust, tobacco smoke and fossil fuels. This substance is used only for research purposes. Dibenzo[a,e]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057766) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 478. 1,3-Bis(2,3-epoxypropoxy)benzene
- [A combustible, yellowish liquid with a slight phenolic odor. Diglycidyl resorcinol ether is used as a liquid spray epoxy resin and in the production of other epoxy resins. Exposure to this substance irritates the eyes, skin and respiratory tract and adversely affects the immune system, central nervous system, liver and gastrointestinal tract. This substance is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0058021) =Organic Chemical; Pharmacologic Substance ;
|
- 429. 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl
- [A synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity. After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and incorporates the 5-prime triphosphate metabolite into RNA, thereby preventing nucleic acid synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0004483) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 479. 1,3-Bis(2-chloroethyl)-1-nitrosourea
- [cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers. ( CSP )] (UMLS (NCI) C0007257) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
nitrosourea;
Antineoplastic Alkylating Agent;
Unclassified Ingredients;
TO BE DELETED INGREDIENT PREPARATIONS;
=CAMUSTINE 7.7 MG;
CARMUSTINE 100 MG;
|
- 430. 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Monohydrochloride
- [The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions. ( NCI )] (UMLS (NCI) C0282369) =Organic Chemical; Pharmacologic Substance ;
=TRAZODONE;
=TRAZODONE HYDROCHLORIDE 150 MG;
TRAZODONE HYDROCHLORIDE 300 MG;
TRAZODONE HYDROCHLORIDE 50 MG;
TRAZODONE HYDROCHLORIDE 100 MG | - 480. 1,3-Butadiene
- [A synthetic, colorless gas that is practically insoluble in water and soluble in ethanol, ether, acetone and benzene. It is used primarily as a monomer to manufacture many different types of polymers and copolymers and as a chemical intermediate in the production of industrial chemicals. When heated, 1,3-butadiene emits acrid fumes and is flammable. In the presence of air, it oxidizes to form explosive peroxides. The primary route of potential human exposure to this compound is inhalation. Acute exposure to 1,3-butadiene can cause irritation of the eyes, nasal passages and throat. At very high concentrations, inhalation of this gas can result in headache, fatigue, decreased blood pressure and pulse rate, central nervous system damage and unconsciousness. It is known to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043902) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 431. 1,2,4-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-, monohydrochloride
- [An alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris. This prevents smooth muscle contraction and results in vasodilatation. Administered in the eye, dapiprazole hydrochloride produces miosis. In the heart, it may antagonize alpha-1 adrenoreceptors in myocytes causing a mild negative inotropic effect. ( NCI )] (UMLS (NCI) C0770916) Dapiprazole Hydrochloride;
DAPIPRAZOLE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =dapiprazole;
=DAPIPRAZOLE HYDROCHLORIDE 0.5 %;
| - 481. 1,3-Diamino-4-methoxybenzene Sulphate
- [A synthetic, off-white to violet solid that is soluble in water and ethanol. It is used primarily as a component of oxidizing 'permanent' hair- and fur-dye formulations. 2,4-Diaminoanisole sulfate is also used as an intermediate in the production of C.I. Basic Brown 2, a dye commonly used in numerous consumer products. The primary routes of potential human exposure to 2,4-diaminoanisole sulfate are dermal contact and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0126603) =Organic Chemical; Pharmacologic Substance
|
- 432. 1,2,4-triglycidylurazol
- [A synthetic triepoxide alkylating agent with cytostatic and immunosuppressant properties. Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. This agent exhibits a broad spectrum of antineoplastic activity against experimental tumors, including those resistant to other alkylating agents. (NCI04) ( NCI )] (UMLS (NCI) C0043767) =Organic Chemical; Pharmacologic Substance ;
| - 482. 1,3-Diamino-4-methylbenzene
- [A synthetic, colorless to brown crystalline solid that is soluble in water, ethanol, ether and benzene. It is used primarily as an intermediate in the production of toluene diisocyanate, which is used to produce polyurethane. Small amounts of 2,4-diaminotoluene are also used to produce dyes for textiles, leathers, furs, and wood and biological stains. When heated to decomposition, it emits toxic fumes of nitrogen oxides. The primary routes of potential human exposure to 2,4-diaminotoluene are dermal contact and inhalation. Contact with this chemical can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045479) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 433. 1,2,5,6 dianhydrogalactitol
- [A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04) ( NCI )] (UMLS (NCI) C0011967) =Carbohydrate; Pharmacologic Substance ;
| - 483. 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl
- [A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04) ( NCI )] (UMLS (NCI) C0075019) =Organic Chemical; Pharmacologic Substance ;
|
- 434. 1,2,5,6-Dibenzacridine
- [A aromatic hydrocarbon consisting of five fused rings formed during the incomplete burning of organic matter. Benz[a,h]acridine is primarily found in petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Benzo[a,h]acridine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0113624) =Organic Chemical; Hazardous or Poisonous Substance
| - 484. 1,3-Diaziridino-2,4,6-Triaza-1,3,5,5-Tetraaminomethyl-1,3,5-Triphosphorin
- [An aziridinyl-substituted cyclophosphazene and a putrescence derivative that may cause DNA cross-linkage. (NCI04) ( NCI )] (UMLS (NCI) C0043914) =Organic Chemical; Pharmacologic Substance ;
|
- 435. 1,2,5,6-Dibenzanthracene
- [A crystalline, carcinogenic aromatic hydrocarbon consisting of five fused benzene rings, produced by the incomplete combustion of organic matter. Dibenzo(a,h)anthracene is primarily found in gasoline exhaust, tobacco smoke, coal tar, soot and certain food products, especially smoked and barbecued foods. This substance is used only for research purposes to induce tumorigenesis. Dibenzo(a,h)anthracene is a mutagen and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0043769) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 485. 1,3-Dichloro-1-propene
- [A synthetic, flammable, colorless liquid that is relatively insoluble in water and soluble in ether, acetone, toluene and benzene. It is used as an intermediate in the manufacture of 3,3-dichloro-1-propene and other pesticides. When heated to decomposition, 1,3-dichloropropene produces toxic fumes of hydrochloric acid and other chlorinated compounds. The primary routes of exposure are inhalation of vapors, dermal contact, and ingestion of contaminated foods and drinking water. Acute exposure can cause irritation of the eyes, skin and mucous membranes. Inhale a low concentration of vapors can result in irritation of the respiratory tract and central nervous system depression. Breathing higher vapor concentrations of this substance may cause coughing, breathing difficulties, substernal pain and extreme respiratory distress. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043918) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 436. 1,2,6,7-Dibenzopyrene
- [A crystalline, aromatic hydrocarbon consisting of six fused rings and formed during the incomplete combustion of organic matter. Dibenzo[a,h]pyrene is primarily found in engine exhaust, cigarette tar and coal tar pitch. Dibenzo[a,h]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057767) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 486. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
- [1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia. ( CSP )] (UMLS (NCI) C0026259) =Organic Chemical; Pharmacologic Substance ;
=anthracene;
Anthracenedione;
[AN000] ANTINEOPLASTICS;
=1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride |
- 437. 1,2,7,8-Dibenzacridine
- [A yellowish aromatic hydrocarbon consisting of five fused rings formed by the incomplete burning of organic matter. Dibenz[a,j]acridine is primarily found in gasoline exhaust, petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Dibenz[a,j]acridine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057761) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 487. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride
- [The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. ( NCI )] (UMLS (NCI) C0700458) =Organic Chemical; Pharmacologic Substance =Mitoxantrone;
=MITOXANTRONE HYDROCHLORIDE 2 MG/ML |
- 438. 1,2,7,8-Dibenzopyrene
- [An aromatic hydrocarbon that consists of six fused rings and is produced by the incomplete combustion of organic matter. Dibenzo[a,i]pyrene is primarily found in gasoline exhaust, tobacco smoke and coal tar. Dibenzo[a,i]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057768) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 488. 1,3-Diisocyanatomethylbenzene
- [A synthetic mixture of the 2,4- and 2,6-isomers is a volatile, colorless to pale yellow liquid that is soluble in many organic solvents. These isomers are used primarily in the synthesis of polyurethane foams. When heated to decomposition, toluene diisocyanate emits toxic fumes of cyanides and nitrogen oxides. Exposure of humans to toluene diisocyanate causes tissue irritation, especially to the mucous membranes, and can produce severe respiratory problems. These isomers are reasonably anticipated to be human carcinogens. (NCI05) ( NCI )] (UMLS (NCI) C0205976) =Organic Chemical; Hazardous or Poisonous Substance
|
- 439. 1,2-(methylenedioxy)benzene
- [formula is C7H6O2; synonyms include: (methylenedioxy)benzene; o-methylenedioxybenzene; benzodioxole; 1,2-(methylenedioxy)benzene; 1,3-dioxaindan; 1,3-dioxindan; 3,4-methylenedioxybenzene. ( CSP )] (UMLS (CSP) C0043896) =Organic Chemical =oxygenous heterocyclic compound;
| - 489. 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine
- [A succinimide with anticonvulsant properties. Although the exact mechanism of action of methsuximide is unclear, it is thought to increase the seizure threshold and suppress the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex and elevation of the threshold of the CNS to convulsive stimuli, probably due to direct modification of membrane function in excitable cells and/or alteration of chemically mediated neurotransmission. ( NCI )] (UMLS (NCI) C0109002) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
succinimide =METHSUXIMIDE 150 MG;
METHSUXIMIDE 300 MG;
|
- 440. 1,2-Benz(a)anthracene
- [A crystalline, aromatic hydrocarbon consisting of four fused benzene rings, produced by incomplete combustion of organic matter. Benz(a)anthracene is primarily found in gasoline and diesel exhaust, tobacco and cigarette smoke, coal tar and coal tar pitch, coal combustion emissions, charcoal-broiled foods, amino acids, fatty acids and carbohydrate pyrolysis products, wood and soot smoke, and creosote, asphalt and mineral oils. This substance is used only for research purposes. Benz(a)anthracene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0220794) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 490. 1,3-Dimethylxanthine Monohydrate
- (UMLS (NCI) C0304443) =Organic Chemical; Pharmacologic Substance
|
- 441. 1,2-Benzenedicarboxylic Acid, Bis(2-ethylhexyl)
- [listed as a plasticizer by USP and MeSH. ( CSP )] (UMLS (NCI) C0012197) =Organic Chemical; Pharmacologic Substance; Biomedical or Dental Material =phthalate;
| - 491. 1,3-Dinitrato-2,2-bis(nitratomethyl)propane
- [The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner. ( NCI )] (UMLS (NCI) C0030858) =Organic Chemical; Pharmacologic Substance ;
=propanediol;
[CV250] ANTIANGINALS =PENTAERYTHRITOL TETRANITRATE 100 MG;
|
- 442. 1,2-Benzisoxazole-3-methanesulfonamide
- [A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hypersynchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA) /benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission. ( NCI )] (UMLS (NCI) C0078844) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
isoxazole =ZONISAMIDE 100 MG | - 492. 1,3-Dinitro-4-chlorobenzene
- [A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds. ( MSH )] (UMLS (NCI) C0012460) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
|
- 443. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine
- (UMLS (NCI) C1450161) =Organic Chemical; Pharmacologic Substance
| - 493. 1,3-Diphenyl-1-triazene
- [An orange crystalline solid compound that is metabolized to benzene in vivo. Diazoaminobenzene is used as a chemical intermediate, complexing agent and polymer additive and is a contaminant in several dyes used in drugs, cosmetics and foods. Diazoaminobenzene is genotoxic in bacteria and rodents. It is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0057742) =Organic Chemical
|
- 444. 1,2-diammino-methy lcyclobutane-platinum (II) lactate
- [An anticancer drug that belongs to the family of drugs called platinum compounds. ( NCI )] (UMLS (NCI) C0165747) =Organic Chemical; Pharmacologic Substance
| - 494. 1,3-Ethylene-2-thiourea
- [A greenish, crystalline compound with a faint amine smell and emits toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition. Ethylene thiourea is mainly used as an accelerator in the production of rubber, and in the manufacture of ethylene bisdithiocarbamate pesticides. This substance is teratogenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0015097) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 445. 1,2-Dibromo-3-chloropropane
- [A dark amber to dark brown colored, halogenated liquid with a pungent odor. Dibromochloropropane is a formerly known pesticide that was used as a soil fumigant and nematocide on crops, and is currently only used as an intermediate in organic synthesis and as a research chemical. Inhalation exposure to this substance results in central nervous system depression and pulmonary edema, while oral exposure causes gastrointestinal distress. Dibromochloropropane is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0043801) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 495. 1,3-Indandione, 2-(p-methoxyphenyl)-
- [A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time. ( NCI )] (UMLS (NCI) C0051919) =Organic Chemical; Pharmacologic Substance ;
=[BL100] ANTICOAGULANTS;
PHENINDIONE =ANISINDIONE 50 MG |
- 446. 1,2-Dibromoethane
- [A clear, colorless, volatile liquid brominated hydrocarbon with a mild, sweet, chloroform-like odor that emits corrosive and toxic fumes when heated to decomposition. Ethylene dibromide is used as a chemical intermediate in the synthesis of resins, waxes, gums, dyes and pharmaceuticals and is used to produce vinyl bromide. Exposure to ethylene dibromide severely irritates the skin and causes depression and collapse. Ethylene dibromide affects DNA integrity by alkylation and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0015079) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 496. 1,3-Propanediol, 2-((3-fluoranthenylmethyl)amino)-2-methyl-
- (UMLS (NCI) C0100007) =Organic Chemical; Pharmacologic Substance ;
|
- 447. 1,2-Dibromopropan-3-ol
- [A synthetic, colorless liquid that is soluble in water, alcohol, ether, benzene and acetone. It is used as an intermediate in the production of flame retardants, insecticides and pharmaceuticals. The primary routes of potential human exposure to 2,3-dibromo-1-propanol are inhalation and dermal contact. Currently, exposure of humans to this chemical is limited to workers who are exposed in an occupational setting. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045359) =Organic Chemical
| - 497. 1,3-Propanediol, 2-Amino-2-(hydroxymethyl)-
- [A member of the pyrrolo-pyrrole group of non-steroidal anti-inflammatory drugs (NSAID) with analgesic, anti-inflammatory, and anti-pyretic properties. Tromethamine inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins. When inhibiting COX2, tromethamine may be effective in relieving pain and inflammation; when inhibiting COX1, this agent may produce unacceptable gastrointestinal side effects. ( NCI )] (UMLS (NCI) C0041175) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =propanediol;
[TN900] THERAPEUTIC NUTRIENTS/MINERALS/ELECTROLYTES, OTHER =Lodoxamide Tromethamine;
(1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1);
TEST;
TROMETHAMINE 18 GM;
TROMETHAMINE 36 GM;
TROMETHAMINE 1.2 MG;
TROMETHAMINE 1.21 MG/ML;
TROMETHAMINE 83 MCG/ML;
|
- 448. 1,2-Dichloroethane
- [A clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0015081) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 498. 1,3-Propanediol, 2-methyl-2-propyl-, Dicarbamate
- [A carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system. ( NCI )] (UMLS (NCI) C0025386) =Organic Chemical; Pharmacologic Substance ;
=carbamate;
[CN309] SEDATIVES/HYPNOTICS, OTHER =MEPROBAMATE 200 MG;
MEPROBAMATE 400 MG;
MEPROBAMATE 600 MG;
|
- 449. 1,2-Dihydro-3-methyl-benz(j)aceanthrylene
- [A polycyclic aromatic hydrocarbon that consists of five fused rings with carcinogenic activity. 20-Methylcholanthrene is often used in experimental cancer studies. ( NCI )] (UMLS (NCI) C0000325) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 499. 1,4 benzenediol
- [1,4-dihydroxybenzene. ( CSP )] (UMLS (CSP) C0020306) =Organic Chemical; Pharmacologic Substance ;
=Hydroquinones;
phenol;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=HYDROQUINONE 2 %;
HYDROQUINONE 3.3 %;
HYDROQUINONE 4 %;
|
- 450. 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide
- [A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04) ( NCI )] (UMLS (NCI) C0244748) =Organic Chemical; Pharmacologic Substance ;
| - 500. 1,4 diazine
- [ ] (UMLS (CSP) C0677630) =Organic Chemical
|
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