[The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions. ( NCI )]
UMLS (NCI) C0282369 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: TRAZODONE
Relation/CHD: TRAZODONE HYDROCHLORIDE 150 MG
TRAZODONE HYDROCHLORIDE 300 MG
TRAZODONE HYDROCHLORIDE 50 MG
TRAZODONE HYDROCHLORIDE 100 MG