- 1. PDGF
- [mitogenic peptide growth hormone carried in the alpha-granules of platelets; released when platelets adhere to traumatized tissues; connective tissue cells near the traumatized region respond by initiating the process of replication. ( CSP )] (UMLS (NCI) C0032200) =Amino Acid, Peptide, or Protein; Biologically Active Substance =blood protein;
Growth Agents;
Peptides;
=platelet-derived growth factor BB | - 5. PDGFRA
- [This gene plays a role in mitogenic activities affecting mesenchymal cells and is involved in receptor tyrosine kinase signal transduction. ( NCI )] (UMLS (NCI) C1335201) PDGFRA Gene;
Platelet-Derived Growth Factor Receptor, Alpha Polypeptide Gene =Gene or Genome |
- 2. PDGF A-Chain
- [Expressed in platelets as 2 alternative isoforms by human PDGFA Gene (PDGF/VEGF Family), Platelet-Derived Growth Factor Alpha is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFA can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Beta. A long PDGFA isoform contains a basic insert that acts as a cell retention signal. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI) ( NCI )] (UMLS (NCI) C1335430) PDGF-1;
PDGFA;
Platelet-Derived Growth Factor A Chain;
Platelet-Derived Growth Factor Alpha;
Platelet-Derived Growth Factor Alpha Polypeptide =Amino Acid, Peptide, or Protein; Hormone | - 6. PDGFRB
- [This gene plays a role in mitogenic activities affecting mesenchymal cells and a translocation in the gene results in chronic myelomonocytic leukemia. ( NCI )] (UMLS (NCI) C1335202) PDGFRB Gene;
Platelet-Derived Growth Factor Receptor, Beta Polypeptide Gene =Gene or Genome |
- 3. PDGF Receptor
- [A cell surface protein that has tyrosine-kinase activity. This receptor specifically binds to platelet derived growth factor, and its analogs and antagonists. Ligand binding causes homodimerization or heterodimerization, resulting in receptor activation. ( NCI )] (UMLS (NCI) C0071253) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
| - 7. PDGFRL
- [This gene may play a role in the negative regulation of cell growth. ( NCI )] (UMLS (NCI) C1335203) PDGFRL Gene;
Platelet-Derived Growth Factor Receptor-Like Gene =Gene or Genome ◊ [Platelet-Derived Growth Factor Receptor-Like Protein, encoded by the PDGFRL gene, has significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. (from LocusLink) ( NCI )] (UMLS (NCI) C1335431) Platelet-Derived Growth Factor Receptor-Like; Platelet-Derived Growth Factor Receptor-Like Protein; Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4. PDGFA
- [This gene plays a role in cellular growth and proliferation. It is also involved in intercellular signaling. ( NCI )] (UMLS (NCI) C1335200) PDGFA Gene;
Platelet-Derived Growth Factor Alpha Polypeptide Gene =Gene or Genome | |
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