- 1. NR0B2
- [This gene is involved in transcriptional regulation and can stimulate transcriptional repression. ( NCI )] (UMLS (NCI) C1334896) NR0B2 Gene;
Nuclear Receptor Subfamily 0, Group B, Member 2 Gene =Gene or Genome ;
◊ [Expressed in small intestine, spleen, liver, heart, adrenal gland, and pancreas, human NR0B2 Gene (NR0 Family) encodes 257-aa 28-kDa Orphan Nuclear Receptor SHP, containing a putative ligand-binding domain and a dimerization domain, but lacking a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression. (NCI) ( NCI )] (UMLS (NCI) C1335142) Nuclear Receptor Subfamily 0 Group B Member 2; Orphan Nuclear Receptor SHP; Short Heterodimer Partner; SHP; SHP1; Amino Acid, Peptide, or Protein; Receptor | |
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