- 1. N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(p-(Dimethylamino)benzyl)-6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-(((3S)-3-quinuclidinylthio)methyl)-12H-pyrido(2,1-f)pyrrolo(2,1-l)(1,4,7,10,13,16)oxapentaazacyclononadecin-9-yl)-
- [A semi-synthetic derivative of pristinamycin, a natural occurring type B streptogramin. Quinupristin binds to the bacterial 50S ribosomal subunit, thereby inhibiting peptide chain elongation, and causing early termination of normal bacterial protein synthesis. Quinupristin is primarily effective against gram-positive cocci. ( NCI )] (UMLS (NCI) C0756081) Quinupristin;
QUINUPRISTIN PREPARATION;
Virginiamycin S1, 4-(4-(dimethylamino)-N-methyl-L-phenylalanine)-5-(5-((1-azabicyclo(2.2.2)oct-3-ylthio)methyl)-4-oxo-L-2-piperidinecarboxylic Acid)-,(S)-;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance =Mikamycin;
[AM900] ANTI-INFECTIVES, OTHER =QUINUPRISTIN 150 MG;
| - 6. NR3C2
- [This gene is involved in transcriptional regulation and signal transduction. ( NCI )] (UMLS (NCI) C1417835) NR3C2 Gene;
Nuclear Receptor Subfamily 3, Group C, Member 2 Gene =Gene or Genome |
- 2. NR0B2
- [This gene is involved in transcriptional regulation and can stimulate transcriptional repression. ( NCI )] (UMLS (NCI) C1334896) NR0B2 Gene;
Nuclear Receptor Subfamily 0, Group B, Member 2 Gene =Gene or Genome ;
◊ [Expressed in small intestine, spleen, liver, heart, adrenal gland, and pancreas, human NR0B2 Gene (NR0 Family) encodes 257-aa 28-kDa Orphan Nuclear Receptor SHP, containing a putative ligand-binding domain and a dimerization domain, but lacking a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression. (NCI) ( NCI )] (UMLS (NCI) C1335142) Nuclear Receptor Subfamily 0 Group B Member 2; Orphan Nuclear Receptor SHP; Short Heterodimer Partner; SHP; SHP1; Amino Acid, Peptide, or Protein; Receptor | - 7. NR4A1
- [This gene is involved in the induction of apoptosis. It also plays a role in regulation of transcription. ( NCI )] (UMLS (NCI) C1367453) NR4A1 Gene;
Nuclear Receptor Subfamily 4, Group A, Member 1 Gene =Gene or Genome |
- 3. NR1F1
- [Encoded by human RORA Gene (NR1 Family) as 4 alternative isoforms, monomeric or homodimeric 556-aa 63-kDa nuclear RAR-Related Orphan Receptor A is an orphan hormone receptor that binds to genomic DNA regulatory elements of hormone-responsive genes containing a single core motif half-site preceded by a short A-T-rich sequence. RORA interacts with nucleoside diphosphate kinase NM23-2, involved in organogenesis and differentiation, as well as with metastasis suppressor NM23-1 gene product. (NCI) ( NCI )] (UMLS (NCI) C0284080) =Amino Acid, Peptide, or Protein; Receptor ;
| - 8. NRAS
- [p21 N-RAS protein is encoded by the N-RAS gene. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form. RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein. This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors. (from OMIM 164790, SWISS-PROT P01111, and NCI) ( NCI )] (UMLS (NCI) C0079975) =Amino Acid, Peptide, or Protein; Enzyme
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- 4. NR2F6
- [This gene is involved in transcriptional regulation and mutations in the gene are associated with the abolishment of transcriptional repression. ( NCI )] (UMLS (NCI) C0812264) NR2F6 Gene;
Nuclear Receptor Subfamily 2, Group F, Member 6 Gene =Gene or Genome | - 9. NRIP1
- [NRIP1 associates directly with a transcriptional activation domain of ESR in the presence of estrogen and modulates transcriptional activation by the receptor. (from OMIM 602490, Swiss-Prot P48552, and NCI) ( NCI )] (UMLS (NCI) C0300807) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 5. NR3C1
- [This gene is involved in ligand-activated transcriptional regulation and mutations in the gene are associated with glucocorticoid resistance. ( NCI )] (UMLS (NCI) C1334899) NR3C1 Gene;
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Gene =Gene or Genome ;
| - 10. NRIP1
- [This gene is involved in regulation of transcription. ( NCI )] (UMLS (NCI) C1334904) NRIP1 Gene;
Nuclear Receptor Interacting Protein 1 Gene;
=Gene or Genome ;
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