- 1. MAP
- [fall into 2 general categories: large motor proteins (dynein, kinesin), and smaller tubulin-crosslinking proteins (tau proteins). ( CSP )] (UMLS (CSP) C0026045) =Amino Acid, Peptide, or Protein; Biologically Active Substance =cytoskeletal protein;
=dynein;
kinesin;
tau protein;
API4 | - 19. MAPK1
- [This gene plays a role in signal transduction and positive regulation of the cell cycle. ( NCI )] (UMLS (NCI) C1366882) MAPK1 Gene;
Mitogen-Activated Protein Kinase 1 wt Allele =Gene or Genome |
- 2. Map
- [A usually 2-dimensional diagrammatic representation of an object or area. ( NCI )] (UMLS (NCI) C0024779) =Manufactured Object; Intellectual Product ;
| - 20. MAPK10
- [This gene plays a role in the regulation of responses to cellular stresses in the central nervous system. ( NCI )] (UMLS (NCI) C1334478) MAPK10 Gene;
Mitogen-Activated Protein Kinase 10 Gene =Gene or Genome ;
|
- 3. MAP
- [The mean pressure of the blood within the arterial circulation. The arterial pressure may be directly measured by insertion of an intra-arterial catheter connected to a transducer. The mean arterial pressure (MAP) can be calculated by subsequent analysis of the waveform. MAP can be approximated without an invasive procedure using the following formula: diastolic pressure plus 1/3 of the pulse pressure, where pulse pressure is systolic pressure - diastolic pressure. (NCI) ( NCI )] (UMLS (NCI) C0428886) =Finding
| - 21. MAPK11
- [This gene is involved in signal transduction and immunity/defense. ( NCI )] (UMLS (NCI) C1366875) MAPK11 Gene;
Mitogen-Activated Protein Kinase 11 Gene =Gene or Genome |
- 4. MAP Kinase 11
- [Encoded by MAPK11 Gene, MAP Kinase 11 is a member of the MAP kinase family, integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI) ( NCI )] (UMLS (NCI) C1456378) MAPK11;
Mitogen-Activated Protein Kinase P38-2;
Stress-Activated Protein Kinase-2;
=Amino Acid, Peptide, or Protein; Enzyme | - 22. MAPK12
- [This gene plays a role in the regulation of cell differentiation. It is also involved in the cellular response to environmental stress. ( NCI )] (UMLS (NCI) C1366897) MAPK12 Gene;
Mitogen-Activated Protein Kinase 12 Gene;
=Gene or Genome ;
|
- 5. MAP Kinase 13
- [Encoded by MAPK13 Gene (MAPK Family), MAP Kinase 13 is closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and cellular stress. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAP kinase kinases 3 and 6 can phosphorylate and activate MAPK13. Transcription factor ATF2, and microtubule dynamics regulator Stathmin have been shown to be the substrates of this kinase. (NCI) ( NCI )] (UMLS (NCI) C1456416) MAP Kinase P38 Delta;
MAPK13;
Mitogen-Activated Protein Kinase P38 Delta;
Stress-Activated Protein Kinase-4 =Amino Acid, Peptide, or Protein; Enzyme | - 23. MAPK13
- [This gene is involved in the cellular response to stress. It also plays a role in the regulation of protein synthesis. ( NCI )] (UMLS (NCI) C1366898) MAPK13 Gene;
Mitogen-Activated Protein Kinase 13 Gene;
=Gene or Genome ;
|
- 6. MAP kinase activator
- [ ] (UMLS (CSP) C0169103) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 24. MAPK14
- [This gene plays a role in stress-related translation and cell cycle regulation. It is also involved in the genotoxic stress response. ( NCI )] (UMLS (NCI) C1366876) MAPK14 Gene;
Mitogen-Activated Protein Kinase 14 Gene =Gene or Genome |
- 7. MAP Kinase Interacting Kinase 1
- [Widely expressed by human MKNK1 Gene (Ser/Thr Kinase Family), alternative 465-aa (51-kDa) and 424-aa MAP Kinase Interacting Kinase 1 isoforms contain a typical Ser/Thr kinase domain, an N-terminal putative NLS, and share homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C- terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation. (NCI) ( NCI )] (UMLS (NCI) C0539636) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 25. MAPK3
- [This gene is involved in signal transduction and positive regulation of the cell cycle. ( NCI )] (UMLS (NCI) C1366765) MAPK3 Gene;
Mitogen-Activated Protein Kinase 3 Gene =Gene or Genome ;
|
- 8. MAP Kinase Interacting Serine/Threonine Kinase 1 Gene
- [This gene is involved in signal transduction and transcriptional regulation. ( NCI )] (UMLS (NCI) C1334509) MKNK1;
MKNK1 Gene;
=Gene or Genome ;
| - 26. MAPK4
- [This gene is involved in cell cycle control and neurogenesis. ( NCI )] (UMLS (NCI) C1334479) MAPK4 Gene;
Mitogen-Activated Protein Kinase 4 Gene =Gene or Genome ;
|
- 9. MAP kinase kinase
- [A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. ( MSH )] (UMLS (CSP) C0169101) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 27. MAPK6
- [This gene plays a role in cell cycle regulation and signal transduction. ( NCI )] (UMLS (NCI) C1334480) MAPK6 Gene;
Mitogen-Activated Protein Kinase 6 Gene =Gene or Genome ;
|
- 10. MAP2K1
- [This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation. ( NCI )] (UMLS (NCI) C1334474) MAP2K1 Gene;
Mitogen-Activated Protein Kinase Kinase 1 Gene =Gene or Genome | - 28. MAPK7
- [This gene is involved in the control of cell proliferation and transcriptional regulation. ( NCI )] (UMLS (NCI) C1334481) MAPK7 Gene;
Mitogen-Activated Protein Kinase 7 Gene =Gene or Genome ;
|
- 11. MAP2K6
- [This gene plays a role in apoptotic regulation by utilizing the MAP kinase signal transduction pathway. ( NCI )] (UMLS (NCI) C1334475) MAP2K6 Gene;
Mitogen-Activated Protein Kinase Kinase 6 Gene =Gene or Genome | - 29. MAPK8
- [This gene plays a role in signal transduction that affects cell differentiation, growth and proliferation. It is also involved in mediation of both insulin resistance and obesity. ( NCI )] (UMLS (NCI) C1367731) MAPK8 Gene;
Mitogen-Activated Protein Kinase 8 Gene =Gene or Genome |
- 12. MAP3K1
- [This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens. ( NCI )] (UMLS (NCI) C1367675) MAP3K1 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene =Gene or Genome ◊ [Encoded by MAP3K1 Gene (MAP3K Family), MEKK1 Protein is pivotal in the Ser/Thr phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1367798) MAPK/ERK Kinase Kinase 1; MEK Kinase; MEK Kinase 1; MEKK1 Protein; Mitogen-Activated Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase 1 Amino Acid, Peptide, or Protein; Enzyme | - 30. MAPK9
- [This gene plays a role in apoptosis, cell differentiation and regulation of transcription during the cellular response to stress. ( NCI )] (UMLS (NCI) C1334482) MAPK9 Gene;
Mitogen-Activated Protein Kinase 9 Gene =Gene or Genome ;
|
- 13. MAP3K14
- [This gene plays a role in signal transduction and apoptosis. It is also involved in both nucleotide and protein binding. ( NCI )] (UMLS (NCI) C1367673) MAP3K14 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase 14 Gene =Gene or Genome | - 31. MAPL BARK-STRIPPRS' LUNG
- [ ] (UMLS (ICD9CM) C0155890) =Disease or Syndrome
|
- 14. MAP3K7
- [This gene plays a role in apoptosis, transcription and the cellular response to stress. ( NCI )] (UMLS (NCI) C1334477) MAP3K7 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase 7 Gene =Gene or Genome | - 32. MAPRE1
- [This gene is involved in the regulation of microtubule assemblies and chromosome stability. ( NCI )] (UMLS (NCI) C1334483) MAPRE1 Gene;
Microtubule-Associated Protein, RP/EB Family, Member 1 Gene =Gene or Genome ;
|
- 15. MAP3K7IP1
- [Encoded by MAP3K7IP1 Gene, ubiquitous 504-amino acid 54.6-kD TAK1-Binding Protein 1 is a MAP3K responsible for mediation of TGF-beta receptor signals and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1321918) Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1;
TAB1 Protein;
TAK1-Binding Protein 1;
Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 33. MapRelationship
- [The closeness or quality of the mapping between the HL7 concept (as represented by the HL7 concept identifier) and the source coding system. The values are patterned after the similar relationships used in the UMLS Metathesaurus. Because the HL7 coding sy ( HL7V3.0 )] (UMLS (HL7) C1553835) =Intellectual Product =CodeSystem;
=Exact;
Broader Than;
Narrower Than;
|
- 16. MAP3K7IP1
- [This gene plays a role in signal transduction and protein binding. ( NCI )] (UMLS (NCI) C1334476) MAP3K7IP1 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 Gene =Gene or Genome | - 34. MAPROTILINE
- [A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. ( MSH )] (UMLS (NCI) C0024778) =Organic Chemical; Pharmacologic Substance ;
=Anthracenes;
[CN609] ANTIDEPRESSANTS, OTHER =1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride |
- 17. MAP3K8
- [This gene is involved in cell growth, survival and proliferation. ( NCI )] (UMLS (NCI) C1337108) MAP3K8 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase 8 Gene;
=Gene or Genome | - 35. Mapuera virus
- [ ] (UMLS (CSP) C0563254) =Virus ;
|
- 18. MAP4K4
- [This gene is plays a role in signal transduction and is putatively involved in the transformation of cells. ( NCI )] (UMLS (NCI) C1367671) MAP4K4 Gene;
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Gene =Gene or Genome | |
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