[Encoded by MAPK11 Gene, MAP Kinase 11 is a member of the MAP kinase family, integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI) ( NCI )]
UMLS (NCI) C1456378MAPK11
Mitogen-Activated Protein Kinase P38-2
Stress-Activated Protein Kinase-2
- Amino Acid, Peptide, or Protein
- Enzyme