- 1. I Kappa B
- [Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI) ( NCI )] (UMLS (NCI) C0167954) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 3. I-Kappa-B-Epsilon
- [Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI) ( NCI )] (UMLS (NCI) C1449065) IKBE;
IKB-Epsilon;
NF-Kappa B Inhibitor Epsilon;
NF-Kappa-B IE;
NFKBIE;
Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Epsilon =Amino Acid, Peptide, or Protein; Biologically Active Substance |
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