[Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI) ( NCI )]
UMLS (NCI) C1449065IKBE
IKB-Epsilon
NF-Kappa B Inhibitor Epsilon
NF-Kappa-B IE
NFKBIE
Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Epsilon
- Amino Acid, Peptide, or Protein
- Biologically Active Substance