[Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI) ( NCI )]
UMLS (NCI) C0167954 - Amino Acid, Peptide, or Protein
- Immunologic Factor
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