- 1. GAB2
- [GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0387800) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 3. GABA aminotransferase
- [An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19. ( MSH )] (UMLS (CSP) C0002543) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 2. GAB2
- [This gene plays a role in signal transduction and regulates T-cell proliferation. It is also involved in bone homeostasis and mediates the differentiation of progenitor cells into osteopaths. ( NCI )] (UMLS (NCI) C1333653) GAB2 Gene;
GRB2-Associated Binding Protein 2 Gene;
=Gene or Genome ;
| - 4. GABA receptor
- [regulate a family of transmembrane chloride channels such that binding of GABA or its analogs permits increased chloride influx, membrane hyperpolarization, and inhibition of postsynaptic electrical activity. ( CSP )] (UMLS (CSP) C0206518) =Amino Acid, Peptide, or Protein; Receptor =neurotransmitter receptor;
chloride channel |
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