- 1. CSAIDS Binding Protein
- [Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, by human MAPK14 Gene (MAPK Family), the four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14 are involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI) ( NCI )] (UMLS (NCI) C1456380) CSBP;
Cytokine Suppressive Anti-Inflammatory Drug Binding Protein; MAP Kinase 14; MAP Kinase Mxi2; MAP Kinase p38Alpha; MAPK14; MAX-Interacting Protein 2; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase p38Alpha; p38 MAP Kinase; p38 MAPK; p38 Mitogen Activated Protein Kinase; p38Alpha EXIP; SAPK2A; Stress-Activated Protein Kinase 2A; =Amino Acid, Peptide, or Protein; Enzyme | |