- 1. CRC18
- [Isolated as a gene in a region frequently deleted in colorectal carcinomas, the DCC gene encodes DCC Protein, which has sequence similarity to cell adhesion molecules such as N-CAM and may participate with other proteins in cell-cell and cell-matrix interactions. It is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM) ( NCI )] (UMLS (NCI) C0289848) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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