[Expressed throughout the enteric and central nervous systems by human NMU Gene (NMU Family), 174-aa 20-kDa (precursor) secreted Neuromedin U (25-aa) is a potent neuropeptide ligand of G Protein-Coupled Receptor 66 and Neuromedin U Receptor 2 (a GPCR) that stimulates smooth muscle contractions of the ileum, urinary bladder, and uterus, increases blood pressure, alters ion transport in the gut, controls local blood flow, and regulates adrenocortical function. The precursor contains a signal peptide and 4 paired basic residues, putative proteolytic processing sites, indicating that the precursor may generate 3 peptides, including NMU located near the C terminus. (NCI) ( NCI )]
UMLS (NCI) C0068605 - Amino Acid, Peptide, or Protein
- Neuroreactive Substance or Biogenic Amine
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