[Bound to NFKB1 or NFKB2 to form NFKB and trapped in the cytoplasm by IkB proteins (primarily through p65), p65 belongs to the Rel/Dorsal family. IKB kinases phosphorylate IkB and activate NFKB via destructive ubiquitination. Translocated, activate NFKB transcription factor binds the enhancer Kappa-B 5'-GGRNNYYCC-3' DNA motif, in immune response and acute phase reaction genes. (from SWISS-PROT Q04206, OMIM 164014, and NCI) ( NCI )]
UMLS (NCI) C0214222 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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