[Ubiquitously expressed by human USF1 Gene, 310-aa 34-kDa nuclear Upstream Stimulatory Factor 1 is a bHLH transcription factor that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein and USF1 can act synergistically with GTF2I to activate transcription. Direct GTF2I interaction requires the USF1 activation and dimerization domains. USF1/USF2A heterodimer represents most USF binding activity. (NCI) ( NCI )]
UMLS (NCI) C1451716Upstream Stimulatory Factor 1
USF1
- Amino Acid, Peptide, or Protein
- Biologically Active Substance