[Globin gene expression is regulated through NFE2 elements upstream of alpha- and beta-gene clusters. NFE2 DNA-binding involves a heterodimer containing a ubiquitous small MAF protein (MAFF, MAFG, or MAFK) and tissue-specific p45 NFE2. Both subunits are members of the AP-1-like superfamily of bZIP proteins. MAFG also forms heterodimers with NRF1 and NFE2-related factor 2, which stimulate transcription from NFE2 sites. (from OMIM 602020 and NCI) ( NCI )]
UMLS (NCI) C0534921 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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