MAD
[Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. MAX Interacting Protein 1, encoded by the MXI1 gene, is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Two transcript variants encoding different isoforms have been identified for the MXI1 gene. (from LocusLink and NCI) ( NCI )]
UMLS (NCI) C0212908- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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