[A cycloheptathiophene derivative with anti-allergic activity. Ketotifen selective blocks histamine (H1) receptors and prevents the typical symptoms caused by histamine release. This agent also interferes with the release of inflammatory mediators from mast cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils. ( NCI )]
UMLS (NCI) C0022642 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: Piperidines
Thiophenes
[OP900] OPHTHALMICS, OTHER
Relation/CHD: 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(E)-2-butenedioate(1:1)