[A botanical formulation with potential chemopreventive activities. Sho-Saiko-to, an herbal mixture containing seven herbal extracts, whose mechanism of action if not fully understood, has shown antiproliferative effects against hepatocellular carcinoma in vitro; other effects described in animal models include the prevention of liver injury and hepatocyte-regenerating activity. Antitumor effects associated with this herbal product may include induction of apoptosis, cell cycle arrest at the G0/G1 phase and activation of an immune response, characterized by the release of cytokines as well as activation of effector cells, such as macrophages and natural killer cells. ( NCI )] (UMLS (NCI) C1138004) Minor Bupleurum Formula; Sho-Saiko-To; Xiao Chai Hu Tang; Xiao-Chai-Hu-Tang; =Pharmacologic Substance ;