[The citrate salt form of enclomiphene, the cis-isomer of clomiphene, a non-steroidal anti-estrogen compound, with anti-infertility and ovulation stimulating properties. Enclomiphene, behaves similar to estrogen, indirectly blocks hypothalamic estrogen receptors, thereby signalling a lack of estrogen to the hypothalamus and inducing a change in pattern of pulsatile release of gonadotropin-releasing hormone (GnRH), which regulates the discharge of follicle-stimulating hormone (FSH) and luteinizing hormone from the anterior pituitary. As a result, enclomiphene disrupts the cycle of pulsatile release of GnRH thereby leading to ovulation. ( NCI )]
UMLS (NCI) C0086214 - Organic Chemical
- Pharmacologic Substance
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